Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.62 |
| ▸ | DRD2 | P14416 | 6/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.58 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.58 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.58 |
| ▸ | DRD3 | P35462 | 3/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6482449 | 0.94 | HTR1A (0.65) | HTR1ADRD2ADRA1AADRA1DADRA1B | |
| SCHEMBL6486916 | 0.85 | DRD2 (0.59) | HTR1ADRD2ADRA1AADRA1DADRA1B | |
| SCHEMBL8651533 | 0.83 | HTR1A (0.57) | HTR1ADRD2ADRA1AADRA1DADRA1B | |
| SCHEMBL6486972 | 0.82 | HTR1A (0.79) | HTR1ADRD2ADRA1AADRA1DADRA1B | |
| SCHEMBL8646293 | 0.81 | HTR1A (0.53) | HTR1ADRD2ADRA1AADRA1DADRA1B | |
| SCHEMBL8643847 | 0.81 | HTR1A (0.51) | HTR1ADRD2ADRA1AADRA1DADRA1B | |
| Hydrochloric Acid SCHEMBL6482862 | 0.81 | HTR1A (0.77) | HTR1ADRD2ADRA1AADRA1DADRA1B | |
| SCHEMBL6547111 | 0.81 | MAPT (0.53) | HTR1ADRD2ADRA1AADRA1DADRA1B | |
| SCHEMBL10753828 | 0.81 | IGF1R (0.63) | HTR1ADRD2ADRA1AADRA1DADRA1B | |
| SCHEMBL8647802 | 0.81 | DRD2 (0.55) | HTR1ADRD2ADRA1AADRA1DADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000046-B1 | PIPERAZINE DERIVATIVES ACTIVE ON THE LOWER URINARY TRACT | RECORDATI CHEM PHARM (CH) | 2003-11-26 | — | — | EP | claimed |
| JP-2001512111-A | — | — | 2001-08-21 | — | — | JP | claimed |
| EP-1000046-A1 | PIPERAZINE DERIVATIVES ACTIVE ON THE LOWER URINARY TRACT | RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY (CH) | 2000-05-17 | — | — | EP | claimed |
| WO-1999006383-A1 | PIPERAZINE DERIVATIVES ACTIVE ON THE LOWER URINARY TRACT | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1999-02-11 | — | — | WO | claimed |
| US-6894052-B1 | Serotonergic receptor antagonist | RECORDATI S.A. CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 2005-05-17 | — | — | US | disclosed |
| EP-1000046-B1 | PIPERAZINE DERIVATIVES ACTIVE ON THE LOWER URINARY TRACT | RECORDATI CHEM PHARM (CH) | 2003-11-26 | — | — | EP | disclosed |