Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CD38 | P28907 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL651425 | 0.91 | MTNR1B (0.35) | ATMPARP1PPARGMAPTGAA | |
| SCHEMBL648253 | 0.83 | TSHR (0.41) | PARP1PPARGMAPTC5AR1 | |
| SCHEMBL650278 | 0.83 | C5AR1 (0.40) | PARP1PPARGL3MBTL1C5AR1 | |
| SCHEMBL648586 | 0.82 | C5AR1 (0.39) | PARP1PPARGMAPTBCHEC5AR1 | |
| SCHEMBL648873 | 0.82 | MC4R (0.37) | ATMPARP1PPARGBCHEMEN1 | |
| SCHEMBL649230 | 0.80 | C5AR1 (0.38) | PARP1PPARGGAAMEN1KMT2A | |
| SCHEMBL651426 | 0.80 | C5AR1 (0.38) | PARP1PPARGGAAMEN1KMT2A | |
| SCHEMBL648105 | 0.78 | C5AR1 (0.38) | PARP1MAPTBCHEMEN1KMT2A | |
| SCHEMBL648963 | 0.78 | C5AR1 (0.54) | PPARGMAPTGAAMEN1KMT2A | |
| SCHEMBL14572934 | 0.76 | PDK1 (0.40) | PARP1PPARGMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |