Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HMOX1 | P09601 | 1/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6487672 | 0.85 | HRH3 (0.38) | ALDH1A1CASP3TMEM97SIGMAR1 | |
| SCHEMBL6496189 | 0.84 | HRH3 (0.39) | ALDH1A1TMEM97SIGMAR1 | |
| SCHEMBL6487261 | 0.84 | TMEM97 (0.42) | ALDH1A1TMEM97SIGMAR1 | |
| SCHEMBL6486752 | 0.84 | TMEM97 (0.36) | ALDH1A1CASP3TP53LMNATMEM97 | |
| SCHEMBL6487338 | 0.83 | TMEM97 (0.47) | ALDH1A1TMEM97SIGMAR1 | |
| SCHEMBL6497464 | 0.83 | DRD3 (0.41) | ALDH1A1TMEM97SIGMAR1 | |
| SCHEMBL6499143 | 0.83 | CYP19A1 (0.37) | TMEM97SIGMAR1OPRM1OPRD1OPRK1 | |
| SCHEMBL6503118 | 0.80 | TMEM97 (0.43) | TMEM97SIGMAR1OPRD1OPRK1 | |
| SCHEMBL6499661 | 0.79 | TMEM97 (0.43) | TMEM97SIGMAR1 | |
| SCHEMBL6485050 | 0.79 | POLB (0.39) | ALDH1A1CASP3PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6869958-B2 | Fused tetrahydropyridine derivatives as matrix metalloproteinase inhibitors | WARNER-LAMBERT COMPANY (US) | 2005-03-22 | — | — | US | disclosed |
| US-20040038960-A1 | Fused tetrahydropyridine derivatives as matrix metalloproteinase inhibitors | LI JIE JACK (US) | 2004-02-26 | — | — | US | disclosed |
| WO-2004014909-A1 | FUSED TETRAHYDROPYRIDINE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040038960-A1 | Fused tetrahydropyridine derivatives as matrix metalloproteinase inhibitors | MMP9, MMP3, MMP13 | ALDH1A1 1071/4885CASP3 920/4885TP53 3469/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.