Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | GABRP | O00591 | 1/20 | 0.51 |
| ▸ | GABRD | O14764 | 1/20 | 0.51 |
| ▸ | IKBKB | O14920 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | CHUK | O15111 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | PIM1 | P11309 | 1/20 | 0.51 |
| ▸ | TOP1 | P11387 | 1/20 | 0.51 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.51 |
| ▸ | IDO1 | P14902 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.51 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.51 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.51 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29951958 | 0.83 | MAPK14 (0.51) | SMN1; SMN2KDM4EGABRPGABRDIKBKB | |
| SCHEMBL2062446 | 0.83 | MAPK14 (0.51) | SMN1; SMN2KDM4EGABRPGABRDIKBKB | |
| 2-Phenyl-1H-Indole-3-Carbaldehyde SCHEMBL1429713 | 0.82 | ESR1 (0.55) | SMN1; SMN2ALDH1A1HPGDMEN1MAPT | |
| SCHEMBL7808349 | 0.82 | CYP11B1 (0.61) | SMN1; SMN2KDM4EGABRPGABRDIKBKB | |
| SCHEMBL29954680 | 0.82 | CYP11B1 (0.61) | SMN1; SMN2KDM4EGABRPGABRDIKBKB | |
| SCHEMBL3598893 | 0.79 | ERN1 (0.47) | SMN1; SMN2AURKAPIM1HPGDCNR1 | |
| SCHEMBL3841034 | 0.78 | ESR1 (0.65) | SMN1; SMN2KDM4EGABRPGABRDIKBKB | |
| SCHEMBL1777845 | 0.77 | ADORA2A (0.50) | SMN1; SMN2AURKAPARP1CNR1IMPDH2 | |
| SCHEMBL16294882 | 0.76 | MAP2 (0.58) | SMN1; SMN2KDM4EGABRPGABRDIKBKB | |
| SCHEMBL29956795 | 0.74 | CHUK (0.47) | SMN1; SMN2KDM4EGABRPGABRDIKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050014942-A1 | Transforming growth factor inhibitor; controllign cell differentiation, cell proliferation | NIPPON SHINYAKU CO., LTD. (JP) | 2005-01-20 | — | — | US | disclosed |
| EP-1452525-A1 | AMIDE DERIVATIVES AND DRUGS | Nippon Shinyaku Co., Ltd. (JP) | 2004-09-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014942-A1 | Transforming growth factor inhibitor; controllign cell differentiation, cell proliferation | TGFBR1, TGFBR2, TGFB1 | SMN1; SMN2 3783/4885KDM4E 756/4885GABRP 3483/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.