Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 8/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.40 |
| ▸ | NOS2 | P35228 | 7/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.35 |
| ▸ | CACNA2D1 | P54289 | 3/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6491591 | 0.90 | NOS2 (0.52) | SLC6A2SLC6A4CYP2D6NOS2S1PR1 | |
| SCHEMBL6504623 | 0.89 | SLC6A2 (0.40) | SLC6A2SLC6A4CYP2D6NOS2CACNA2D1 | |
| SCHEMBL7174582 | 0.89 | SLC6A2 (0.40) | SLC6A2SLC6A4CYP2D6NOS2CACNA2D1 | |
| Oxalic Acid SCHEMBL6488920 | 0.88 | SLC6A2 (0.46) | SLC6A2SLC6A4CYP2D6NOS2S1PR1 | |
| SCHEMBL6491866 | 0.88 | SLC6A4 (0.53) | SLC6A2SLC6A4CYP2D6NOS2KCNH2 | |
| SCHEMBL6492890 | 0.85 | NOS2 (0.40) | SLC6A2SLC6A4CYP2D6NOS2KCNH2 | |
| SCHEMBL6503637 | 0.84 | NOS2 (0.54) | SLC6A2SLC6A4CYP2D6NOS2S1PR1 | |
| Oxalic Acid SCHEMBL6489765 | 0.80 | CYP2D6 (0.44) | SLC6A2SLC6A4CYP2D6NOS2S1PR1 | |
| SCHEMBL7648418 | 0.79 | SLC6A2 (0.38) | SLC6A2SLC6A4CYP2D6NOS2CACNA2D1 | |
| SCHEMBL6504778 | 0.79 | SLC6A2 (0.38) | SLC6A2SLC6A4CYP2D6NOS2CACNA2D1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6887871-B2 | Use of phenylheteroakylamine derivatives | ASTRAZENECA AB (SE) | 2005-05-03 | — | — | US | disclosed |
| US-20030158185-A1 | Novel use of phenylheteroakylamine derivatives | ASTRAZENECA AB (SE) | 2003-08-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030158185-A1 | Novel use of phenylheteroakylamine derivatives | NOS1, XDH, NOS2 | SLC6A2 1776/4885SLC6A4 2468/4885CYP2D6 49/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.