Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 6/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 6/20 | 0.36 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.36 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.36 |
| ▸ | ITGAL | P20701 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | PRCP | P42785 | 2/20 | 0.35 |
| ▸ | LIPE | Q05469 | 5/20 | 0.34 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4847817 | 0.92 | KCNN3 (0.38) | METAP2HCRTR1HCRTR2CYP3A4GRM2 | |
| SCHEMBL14254856 | 0.89 | METAP2 (0.39) | METAP2HCRTR1HCRTR2ITGB2ICAM1 | |
| SCHEMBL4841746 | 0.89 | METAP2 (0.39) | METAP2HCRTR1HCRTR2ITGB2ICAM1 | |
| SCHEMBL4841580 | 0.87 | METAP2 (0.39) | METAP2HCRTR1HCRTR2ITGB2ICAM1 | |
| SCHEMBL4847332 | 0.84 | ITGAL (0.52) | ITGB2ICAM1ITGAL | |
| SCHEMBL6478278 | 0.84 | ITGAL (0.52) | ITGB2ICAM1ITGAL | |
| SCHEMBL4844861 | 0.83 | METAP2 (0.39) | METAP2HCRTR1HCRTR2SCN9ALIPE | |
| SCHEMBL4848499 | 0.83 | SCN9A (0.42) | METAP2HCRTR1HCRTR2ITGB2ICAM1 | |
| SCHEMBL4848356 | 0.83 | METAP2 (0.37) | METAP2HCRTR1HCRTR2ITGB2ICAM1 | |
| SCHEMBL6490093 | 0.82 | METAP2 (0.37) | METAP2HCRTR1HCRTR2ITGB2ICAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6897225-B1 | Inhibitors of αLβ2 mediated cell adhesion | TANABE SEIYAKU CO., LTD. (JP) | 2005-05-24 | — | — | US | disclosed |