Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | BRAF | P15056 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CLK1 | P49759 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | UBE2M | P61081 | 1/20 | 0.40 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4859619 | 0.91 | SMN1; SMN2 (0.56) | L3MBTL1ALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL2949934 | 0.87 | NPC1 (0.60) | L3MBTL1ALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL2950542 | 0.85 | L3MBTL1 (0.63) | L3MBTL1ALDH1A1BRAFSMN1; SMN2NPC1 | |
| SCHEMBL2960922 | 0.83 | L3MBTL1 (0.57) | L3MBTL1ALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL6585821 | 0.81 | BRAF (0.47) | L3MBTL1ALDH1A1BRAFSMN1; SMN2NPC1 | |
| SCHEMBL7153301 | 0.80 | HTR2A (0.54) | L3MBTL1ALDH1A1NPC1RAB9A | |
| SCHEMBL27589543 | 0.80 | L3MBTL1 (0.56) | L3MBTL1ALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL2960343 | 0.80 | FPR2 (0.56) | L3MBTL1ALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL2956954 | 0.79 | L3MBTL1 (0.57) | L3MBTL1ALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL6585825 | 0.79 | BRAF (0.48) | L3MBTL1ALDH1A1BRAFSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6846919-B2 | Non-endogenous, constitutively activated human serotonin receptors and small molecule modulators thereof | ARENA PHARMACEUTICALS, INC. (US) | 2005-01-25 | — | — | US | disclosed |
| CN-1411448-A | Pyrazole derivatives which modulate human 5-serotonin receptors | ARENA PHARM INC (US) | 2003-04-16 | — | — | CN | disclosed |
| US-6541209-B1 | Bioassay; identification of compounds as agonists; use in treatment of diseases and disorders that are related to 5-HT2A and or 5-HT2C serotonin receptors | ARENA PHARMACEUTICALS, INC. | 2003-04-01 | — | — | US | disclosed |
| US-6420541-B1 | MEMBRANE PROTEIN FOR USE IN TREATING PSYCHOLOGICAL, NERVOUS SYSTEM, EATING AND SEXUAL DISORDERS | ARENA PHARMACEUTICALS, INC. | 2002-07-16 | — | — | US | disclosed |
| US-6140509-A | Non-endogenous, constitutively activated human serotonin receptors and small molecule modulators thereof | ARENA PHARMACEUTICALS, INC. (US) | 2000-10-31 | — | — | US | disclosed |