Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | QPCT | Q16769 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | FBP1 | P09467 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6490218 | 0.91 | L3MBTL1 (0.54) | SMN1; SMN2LMNAL3MBTL1ALDH1A1RXFP1 | |
| SCHEMBL2949934 | 0.89 | NPC1 (0.60) | SMN1; SMN2L3MBTL1ALDH1A1ROCK2MEN1 | |
| SCHEMBL2950542 | 0.85 | L3MBTL1 (0.63) | SMN1; SMN2LMNAL3MBTL1ALDH1A1ROCK2 | |
| SCHEMBL2955962 | 0.85 | MAPT (0.50) | SMN1; SMN2LMNAL3MBTL1ALDH1A1GAA | |
| SCHEMBL2960922 | 0.85 | L3MBTL1 (0.57) | SMN1; SMN2LMNAL3MBTL1ALDH1A1GAA | |
| SCHEMBL7153301 | 0.82 | HTR2A (0.54) | L3MBTL1ALDH1A1NPC1RAB9A | |
| SCHEMBL6586589 | 0.81 | SMN1; SMN2 (0.56) | SMN1; SMN2LMNAL3MBTL1ALDH1A1RXFP1 | |
| SCHEMBL2960343 | 0.81 | FPR2 (0.56) | SMN1; SMN2LMNAL3MBTL1ALDH1A1ROCK2 | |
| SCHEMBL27589543 | 0.80 | L3MBTL1 (0.56) | SMN1; SMN2L3MBTL1ALDH1A1GAAMEN1 | |
| SCHEMBL6160579 | 0.79 | BRD4 (0.49) | L3MBTL1RXFP1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7368539-B2 | Non-endogenous, constitutively activated human serotonin receptors and small molecule modulators thereof | ARENA PHARMACEUTICALS, INC. (US) | 2008-05-06 | — | — | US | disclosed |
| US-20050119182-A1 | Non-endogenous, constitutively activated human serotonin receptors and small molecule modulators thereof | ARENA PHARMACEUTICALS, INC. (US) | 2005-06-02 | — | — | US | disclosed |
| CN-1411448-A | Pyrazole derivatives which modulate human 5-serotonin receptors | ARENA PHARM INC (US) | 2003-04-16 | — | — | CN | disclosed |
| US-6541209-B1 | Bioassay; identification of compounds as agonists; use in treatment of diseases and disorders that are related to 5-HT2A and or 5-HT2C serotonin receptors | ARENA PHARMACEUTICALS, INC. | 2003-04-01 | — | — | US | disclosed |
| US-6420541-B1 | MEMBRANE PROTEIN FOR USE IN TREATING PSYCHOLOGICAL, NERVOUS SYSTEM, EATING AND SEXUAL DISORDERS | ARENA PHARMACEUTICALS, INC. | 2002-07-16 | — | — | US | disclosed |
| US-6140509-A | Non-endogenous, constitutively activated human serotonin receptors and small molecule modulators thereof | ARENA PHARMACEUTICALS, INC. (US) | 2000-10-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050119182-A1 | Non-endogenous, constitutively activated human serotonin receptors and small molecule modulators thereof | HTR2A, HTR3B, HTR3A | SMN1; SMN2 4539/4885LMNA 4266/4885L3MBTL1 4160/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.