Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NHERF1 | O14745 | 2/20 | 0.47 |
| ▸ | CFTR | P13569 | 2/20 | 0.40 |
| ▸ | SLC16A3 | O15427 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5755838 | 0.83 | BRAF (0.44) | CFTRMEN1KMT2AHDAC11CHRNB2 | |
| SCHEMBL5756316 | 0.80 | KDM4E (0.53) | MEN1KMT2ARXFP1CHRNB2CHRNB4 | |
| SCHEMBL6489406 | 0.80 | NHERF1 (0.50) | NHERF1SLC16A3MEN1KMT2AMAPT | |
| SCHEMBL6488486 | 0.80 | ITK (0.48) | NHERF1SLC16A3MAPTTP53 | |
| SCHEMBL5757017 | 0.79 | HDAC11 (0.43) | HDAC11ALDH1A1MAPTTP53KDM4E | |
| SCHEMBL5754686 | 0.78 | KDR (0.43) | HDAC11MAPTKDM4E | |
| SCHEMBL5756000 | 0.78 | MEN1 (0.46) | MEN1KMT2AHDAC11ALDH1A1MAPT | |
| SCHEMBL6490354 | 0.77 | ALDH1A1 (0.44) | MEN1KMT2AALDH1A1MAPTKDM4E | |
| SCHEMBL5752672 | 0.77 | HDAC11 (0.41) | MEN1KMT2AHDAC11ALDH1A1MAPT | |
| SCHEMBL6488444 | 0.77 | HDAC1 (0.44) | MEN1KMT2AHDAC11ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050032869-A1 | Pyrazolyl-indole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PHARMACIA ITALIA S.P.A. (IT) | 2005-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050032869-A1 | Pyrazolyl-indole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | MAP3K9, MAP3K20, MAP3K19 | NHERF1 3673/4885CFTR 3166/4885SLC16A3 4882/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.