Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 15/20 | 0.48 |
| ▸ | NHERF1 | O14745 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | INSR | P06213 | 2/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6489406 | 0.92 | NHERF1 (0.50) | ITKNHERF1TP53MAPTSLC16A3 | |
| SCHEMBL5754385 | 0.83 | ITK (0.53) | ITKINSRCCNE1CDK2CASP3 | |
| SCHEMBL5756912 | 0.80 | ITK (0.66) | ITKINSRCCNE1CDK2 | |
| SCHEMBL6490316 | 0.80 | NHERF1 (0.47) | NHERF1TP53MAPTSLC16A3 | |
| SCHEMBL5755010 | 0.78 | ITK (0.62) | ITKINSRCCNE1CDK2 | |
| SCHEMBL5756552 | 0.77 | ITK (0.51) | ITKINSRCCNE1CDK2 | |
| SCHEMBL5752622 | 0.77 | ITK (0.50) | ITKMAPTINSRCCNE1CDK2 | |
| SCHEMBL6489347 | 0.76 | ITK (0.44) | ITKTP53MAPT | |
| SCHEMBL5754383 | 0.76 | ROCK2 (0.52) | ITKINSRCCNE1CDK2CASP3 | |
| SCHEMBL5757838 | 0.76 | ITK (0.49) | ITKMAPTINSRCCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050032869-A1 | Pyrazolyl-indole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PHARMACIA ITALIA S.P.A. (IT) | 2005-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050032869-A1 | Pyrazolyl-indole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | MAP3K9, MAP3K20, MAP3K19 | ITK 392/4885NHERF1 3673/4885TP53 317/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.