Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 4/20 | 0.47 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.47 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.47 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 2/20 | 0.43 |
| ▸ | MMP9 | P14780 | 2/20 | 0.43 |
| ▸ | MMP7 | P09237 | 3/20 | 0.41 |
| ▸ | MMP3 | P08254 | 2/20 | 0.41 |
| ▸ | MMP10 | P09238 | 2/20 | 0.41 |
| ▸ | MMP8 | P22894 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6479009 | 0.89 | MMP12 (0.58) | MMP12ADAM17ADAMTS4ADAMTS5MMP2 | |
| SCHEMBL6489505 | 0.84 | ADAM17 (0.60) | MMP12ADAM17ADAMTS4ADAMTS5MMP2 | |
| SCHEMBL6491584 | 0.84 | ADAM17 (0.60) | MMP12ADAM17ADAMTS4ADAMTS5MMP2 | |
| SCHEMBL6489627 | 0.82 | ADAM17 (0.68) | MMP12ADAM17ADAMTS4ADAMTS5MMP2 | |
| SCHEMBL6480440 | 0.79 | MMP2 (0.60) | MMP12ADAM17ADAMTS4ADAMTS5MMP2 | |
| SCHEMBL6480002 | 0.77 | MMP12 (0.60) | MMP12ADAM17ADAMTS4ADAMTS5MMP2 | |
| SCHEMBL6492853 | 0.77 | MMP2 (0.58) | MMP12ADAM17ADAMTS4ADAMTS5MMP2 | |
| SCHEMBL6487834 | 0.77 | MMP2 (0.55) | MMP12ADAM17ADAMTS4ADAMTS5MMP2 | |
| SCHEMBL6490454 | 0.76 | MMP2 (0.55) | MMP12ADAM17ADAMTS4ADAMTS5MMP2 | |
| SCHEMBL6491200 | 0.76 | MMP2 (0.55) | MMP12ADAM17ADAMTS4ADAMTS5MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6962938-B2 | Spiro-cyclic β-amino acid derivatives as inhibitors of matrix metalloproteases and TNF-α converting enzyme (TACE) | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2005-11-08 | — | — | US | claimed |