Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 5/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | PLEC | Q15149 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6527932 | 0.89 | KDM4E (0.49) | KDM4EALDH1A1TAAR1GAAKDM1A | |
| SCHEMBL2865070 | 0.84 | ALDH1A1 (0.54) | KDM4EALDH1A1TAAR1GAAKDM1A | |
| SCHEMBL6493317 | 0.80 | KDM4E (0.48) | KDM4EALDH1A1TAAR1GAAHSD17B10 | |
| SCHEMBL2872967 | 0.79 | KDM1A (0.46) | KDM4EALDH1A1TAAR1GAAKDM1A | |
| SCHEMBL2868863 | 0.77 | ALDH1A1 (0.58) | KDM4EALDH1A1TAAR1GAAHSD17B10 | |
| SCHEMBL2870661 | 0.76 | ALDH1A1 (0.67) | KDM4EALDH1A1TAAR1GAAKDM1A | |
| SCHEMBL2869386 | 0.76 | ALDH1A1 (0.67) | KDM4EALDH1A1TAAR1GAAKDM1A | |
| SCHEMBL2872252 | 0.74 | ALDH1A1 (0.47) | KDM4EALDH1A1TAAR1GAAHSD17B10 | |
| SCHEMBL2872441 | 0.73 | ALDH1A1 (0.56) | KDM4EALDH1A1TAAR1GAAHSD17B10 | |
| SCHEMBL2876072 | 0.73 | HPGD (0.53) | KDM4EALDH1A1TAAR1GAAKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050245586-A1 | 2,5-Dioxoimidazolidin-4-yl acetamides and analogues as inhibitors of metalloproteinase mmp12 | ASTRAZENECA AB (SE) | 2005-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245586-A1 | 2,5-Dioxoimidazolidin-4-yl acetamides and analogues as inhibitors of metalloproteinase mmp12 | MMP12, PDE12, MMP13 | KDM4E 553/4885ALDH1A1 441/4885TAAR1 3540/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.