Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 6/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CACNA2D1 | P54289 | 3/20 | 0.39 |
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | HTR7 | P34969 | 3/20 | 0.38 |
| ▸ | HTR6 | P50406 | 3/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | CTSA | P10619 | 4/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | SCN1A | P35498 | 1/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6493257 | 1.00 | NOS2 (0.47) | NOS2SLC6A2SLC6A4CYP2D6CACNA2D1 | |
| Hydrochloric Acid SCHEMBL6491805 | 0.99 | NOS2 (0.46) | NOS2SLC6A2SLC6A4CYP2D6CACNA2D1 | |
| Hydrochloric Acid SCHEMBL6491813 | 0.99 | NOS2 (0.46) | NOS2SLC6A2SLC6A4CYP2D6CACNA2D1 | |
| SCHEMBL6499946 | 0.85 | NOS2 (0.61) | NOS2SLC6A2SLC6A4CYP2D6CACNA2D1 | |
| Hydrochloric Acid SCHEMBL6493136 | 0.84 | NOS2 (0.60) | NOS2SLC6A2SLC6A4CYP2D6CACNA2D1 | |
| SCHEMBL6577551 | 0.78 | SLC7A5 (0.41) | SLC6A2SLC6A4CACNA2D1HTR2ACTSA | |
| SCHEMBL6576551 | 0.78 | NOS2 (0.54) | NOS2SLC6A2SLC6A4CYP2D6CACNA2D1 | |
| Hydrochloric Acid SCHEMBL6576519 | 0.78 | NOS2 (0.53) | NOS2SLC6A2SLC6A4CYP2D6CACNA2D1 | |
| SCHEMBL6493266 | 0.76 | NOS2 (0.39) | NOS2CTSA | |
| SCHEMBL6490842 | 0.75 | NOS2 (0.47) | NOS2SLC6A2SLC6A4CYP2D6DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6887871-B2 | Use of phenylheteroakylamine derivatives | ASTRAZENECA AB (SE) | 2005-05-03 | — | — | US | disclosed |
| EP-1263711-B1 | NOVEL USE OF PHENYLHETEROALKYLAMINE DERIVATIVES | ASTRAZENECA AB (SE) | 2004-12-15 | — | — | EP | disclosed |
| US-20030158185-A1 | Novel use of phenylheteroakylamine derivatives | ASTRAZENECA AB (SE) | 2003-08-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030158185-A1 | Novel use of phenylheteroakylamine derivatives | NOS1, XDH, NOS2 | NOS2 3/4885SLC6A2 1776/4885SLC6A4 2468/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.