Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 2/20 | 0.36 |
| ▸ | ITGB2 | P05107 | 6/20 | 0.35 |
| ▸ | ICAM1 | P05362 | 6/20 | 0.35 |
| ▸ | ITGAL | P20701 | 6/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | TACR2 | P21452 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5829934 | 0.84 | EPHX2 (0.40) | PDE7ALMNAMAPTALDH1A1RAB9A | |
| SCHEMBL5830031 | 0.83 | PDE7A (0.44) | PDE7AITGB2ICAM1ITGALLMNA | |
| SCHEMBL6494066 | 0.82 | AKR1C3 (0.40) | PDE7ALMNAMAPTALDH1A1RAB9A | |
| SCHEMBL5830183 | 0.81 | PDE7A (0.36) | PDE7AITGB2ICAM1ITGALLMNA | |
| SCHEMBL5836083 | 0.81 | ITGAL (0.41) | PDE7AITGB2ICAM1ITGALLMNA | |
| SCHEMBL6197862 | 0.80 | PDE7A (0.41) | PDE7AITGB2ICAM1ITGALLMNA | |
| SCHEMBL7702269 | 0.77 | ITGB2 (0.48) | PDE7AITGB2ICAM1ITGALLMNA | |
| SCHEMBL5830812 | 0.75 | SPR (0.42) | PDE7ALMNAMAPTALDH1A1RAB9A | |
| SCHEMBL5830364 | 0.75 | PDE7A (0.38) | PDE7ALMNAMAPTALDH1A1RAB9A | |
| SCHEMBL5830870 | 0.72 | NOTUM (0.44) | ITGB2ICAM1ITGALMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6878700-B1 | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds | ABBOTT LABORATORIES (US) | 2005-04-12 | — | — | US | disclosed |