Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 10/20 | 0.48 |
| ▸ | ICAM1 | P05362 | 10/20 | 0.48 |
| ▸ | ITGAL | P20701 | 10/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PHGDH | O43175 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5830031 | 0.89 | PDE7A (0.44) | ITGB2ICAM1ITGALKMT2AALDH1A1 | |
| SCHEMBL6197862 | 0.86 | PDE7A (0.41) | ITGB2ICAM1ITGALKMT2AALDH1A1 | |
| SCHEMBL5836083 | 0.85 | ITGAL (0.41) | ITGB2ICAM1ITGALALDH1A1LMNA | |
| SCHEMBL5830812 | 0.82 | SPR (0.42) | KMT2AALDH1A1LMNAPDE7AHPGD | |
| SCHEMBL6317025 | 0.82 | ITGAL (0.43) | ITGB2ICAM1ITGALKMT2AALDH1A1 | |
| SCHEMBL5830183 | 0.78 | PDE7A (0.36) | ITGB2ICAM1ITGALALDH1A1LMNA | |
| SCHEMBL6494066 | 0.77 | AKR1C3 (0.40) | KMT2AALDH1A1LMNAPDE7AHPGD | |
| SCHEMBL6494059 | 0.77 | PDE7A (0.36) | ITGB2ICAM1ITGALKMT2AALDH1A1 | |
| SCHEMBL5830288 | 0.77 | HSD11B1 (0.49) | ALDH1A1 | |
| SCHEMBL5830364 | 0.76 | PDE7A (0.38) | KMT2AALDH1A1LMNAPDE7APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165505-A1 | CELL ADHESION-INHIBITING ANTIINFLAMMATORY AND IMMUNE-SUPPRESSIVE COMPOUNDS | ABBOTT LABORATORIES (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059880-A1 | CELL ADHESION-INHIBITING ANTIINFLAMMATORY AND IMMUNE-SUPPRESSIVE COMPOUNDS | ABBOTT LABORATORIES (US) | 2000-10-12 | — | — | WO | disclosed |