Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 6/20 | 0.53 |
| ▸ | CHRNB4 | P30926 | 6/20 | 0.53 |
| ▸ | CHRNA3 | P32297 | 6/20 | 0.53 |
| ▸ | CHRNA4 | P43681 | 6/20 | 0.53 |
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3579980 | 0.86 | CHRNB2 (0.58) | CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL652005 | 0.84 | CHRNB2 (0.52) | CHRNB2CHRNB4CHRNA3CHRNA4GPR119 | |
| SCHEMBL650042 | 0.84 | CHRNB2 (0.52) | CHRNB2CHRNB4CHRNA3CHRNA4GPR119 | |
| SCHEMBL649855 | 0.83 | GPR119 (0.69) | CHRNB2CHRNB4CHRNA3CHRNA4GPR119 | |
| SCHEMBL649395 | 0.83 | GPR119 (0.69) | CHRNB2CHRNB4CHRNA3CHRNA4GPR119 | |
| SCHEMBL652471 | 0.80 | GPR119 (0.47) | GPR119USP30 | |
| SCHEMBL653184 | 0.79 | CHRNB2 (0.49) | CHRNB2CHRNB4CHRNA3CHRNA4GPR119 | |
| SCHEMBL650797 | 0.79 | CHRNB2 (0.47) | CHRNB2CHRNB4CHRNA3CHRNA4GPR119 | |
| SCHEMBL652111 | 0.79 | CHRNB2 (0.49) | CHRNB2CHRNB4CHRNA3CHRNA4GPR119 | |
| SCHEMBL654584 | 0.79 | CHRNB2 (0.47) | CHRNB2CHRNB4CHRNA3CHRNA4GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119635-B2 | Diazabicyclic central nervous system active agents | ABBOTT LABORATORIES (US) | 2012-02-21 | — | — | US | disclosed |
| EP-2298775-A1 | Diazabicyclic central nervous system active agents | Abbott Laboratories (US) | 2011-03-23 | — | — | EP | disclosed |
| EP-2295437-A1 | Diazabicyclic central nervous system active agents | Abbott Laboratories (US) | 2011-03-16 | — | — | EP | disclosed |