Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 2/20 | 0.56 |
| ▸ | HSD11B1 | P28845 | 9/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.53 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.53 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.53 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | PLD2 | O14939 | 2/20 | 0.48 |
| ▸ | PLD1 | Q13393 | 2/20 | 0.48 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6494183 | 1.00 | CCR5 (0.56) | CCR5HSD11B1CHRM2CHRM4CHRM1 | |
| SCHEMBL5956482 | 0.94 | CCR5 (0.60) | CCR5HSD11B1CHRM2CHRM4CHRM1 | |
| SCHEMBL16657347 | 0.89 | CCR5 (0.56) | CCR5HSD11B1CHRM2CHRM4CHRM1 | |
| SCHEMBL15575621 | 0.88 | CCR5 (0.45) | CCR5HSD11B1CHRM2CHRM4CHRM1 | |
| SCHEMBL13243455 | 0.88 | CHRM1 (0.67) | CCR5HSD11B1CHRM2CHRM4CHRM1 | |
| SCHEMBL3004078 | 0.88 | CHRM1 (0.67) | CCR5HSD11B1CHRM2CHRM4CHRM1 | |
| SCHEMBL2989677 | 0.87 | CHRM1 (0.68) | CCR5HSD11B1CHRM2CHRM4CHRM1 | |
| SCHEMBL18764531 | 0.86 | CYP2C9 (0.48) | CCR5 | |
| SCHEMBL31437335 | 0.86 | CYP2C9 (0.48) | CCR5 | |
| SCHEMBL20450661 | 0.86 | CYP2C9 (0.48) | CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6946477-B2 | 3-Substituted piperidines comprising urea functionality, and methods of use thereof | SEPRACOR INC. (US) | 2005-09-20 | — | — | US | disclosed |
| US-6476050-B2 | ANALGESICS; LIGANDS FOR VARIOUS CELLULAR RECEPTORS, INCLUDING OPIOID RECEPTORS, OTHER G-PROTEIN-COUPLED RECEPTORS AND ION CHANNELS | SEPRACOR, INC. | 2002-11-05 | — | — | US | disclosed |
| US-20010056090-A1 | 3-substituted piperidines comprising urea functionality, and methods of use thereof | SEPRACOR INC. | 2001-12-27 | — | — | US | disclosed |
| WO-2001068604-A2 | 3-SUBSTITUTED PIPERIDINES COMPRISING UREA FUNCTIONALITY, AND METHODS OF USE THEREOF | SEPRACOR, INC. (US) | 2001-09-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010056090-A1 | 3-substituted piperidines comprising urea functionality, and methods of use thereof | OPRM1, OPRL1, OPRK1 | CCR5 607/4885HSD11B1 4754/4885CHRM2 284/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.