Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 17/20 | 0.74 |
| ▸ | GRIA2 | P42262 | 11/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7141890 | 0.80 | GRIK1 (0.76) | GRIK1GRIA2 | |
| Hydrochloric Acid SCHEMBL6498579 | 0.80 | GRIK1 (0.72) | GRIK1GRIA2 | |
| SCHEMBL6487605 | 0.78 | GRIK1 (0.45) | GRIK1ALDH1A1 | |
| SCHEMBL19915084 | 0.74 | ALOX15 (0.62) | ALDH1A1 | |
| SCHEMBL6485218 | 0.73 | GRIK1 (0.61) | GRIK1GRIA2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6485210 | 0.72 | GRIK1 (0.60) | GRIK1GRIA2ALDH1A1 | |
| SCHEMBL5833031 | 0.69 | RAB9A (0.54) | ALDH1A1 | |
| SCHEMBL6488414 | 0.69 | GRIK1 (1.00) | GRIK1GRIA2 | |
| Hydrochloric Acid SCHEMBL6486373 | 0.68 | GRIK1 (0.98) | GRIK1GRIA2 | |
| SCHEMBL3911935 | 0.67 | GRIK1 (0.78) | GRIK1GRIA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6924294-B2 | Excitatory amino acid receptor antagonists | ELI LILLY AND COMPANY (US) | 2005-08-02 | — | — | US | disclosed |
| US-20040053961-A1 | Excitatory amino acid receptor antagonists | ELI LILLY AND COMPANY | 2004-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040053961-A1 | Excitatory amino acid receptor antagonists | SLC1A2, SLC1A1, SLC1A3 | GRIK1 12/4885GRIA2 24/4885ALDH1A1 1762/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.