SCHEMBL6495187

SCHEMBL6495187

Cn1c(C(F)(F)F)nn(-c2ccc(C#N)cc2F)c1=O

nearest known ligand 0.43

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.43
PRKDC P78527 3/20 0.41
DHODH Q02127 6/20 0.41
CTSK P43235 1/20 0.40
CASP3 P42574 1/20 0.39
ATM Q13315 1/20 0.36
GPR119 Q8TDV5 1/20 0.35
OPRM1 P35372 1/20 0.35
OPRL1 P41146 1/20 0.35
ADRA1D P25100 1/20 0.34
ADRA1A P35348 1/20 0.34
ADRA1B P35368 1/20 0.34
SLC6A9 P48067 1/20 0.34
KCNH2 Q12809 1/20 0.34
KIF11 P52732 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6495847 0.86 AR (0.44) L3MBTL1DHODHCTSKCASP3OPRM1
SCHEMBL6495586 0.85 PRKDC (0.36) L3MBTL1PRKDCCTSKCASP3GPR119
SCHEMBL6103445 0.81 DHODH (0.42) L3MBTL1DHODHCTSK
SCHEMBL6498158 0.75 DHODH (0.38) L3MBTL1DHODHCTSKATM
SCHEMBL25181318 0.74 KDM4E (0.40) PRKDCGPR119SLC6A9KCNH2KIF11
SCHEMBL30443258 0.74 KDM4E (0.40) PRKDCGPR119SLC6A9KCNH2KIF11
SCHEMBL6106477 0.72 DHODH (0.40) DHODHCTSKKIF11
SCHEMBL6308458 0.71 PGR (0.40) DHODHCTSK
SCHEMBL31470297 0.71 CTSK (0.37) DHODHCTSK
SCHEMBL21001114 0.71 CTSK (0.37) DHODHCTSK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6906006-B1 N-arly-substituted nitrogen-containing heterocycles, processes and novel intermediates for their preparation, and their use as herbicides and plant growth regulators BAYER AKTIENGESELLSCHAFT (DE) 2005-06-14 US claimed