Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 2/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6495234 | 1.00 | PIN1 (0.47) | PIN1SMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL10525181 | 0.84 | PIN1 (0.49) | PIN1SMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL11171940 | 0.84 | PIN1 (0.49) | PIN1SMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL8985655 | 0.83 | CHRNB2 (0.47) | SMN1; SMN2KMT2ANPC1CHRNB2CHRNB4 | |
| SCHEMBL9191050 | 0.82 | KMT2A (0.48) | MEN1KMT2ACHRNB2CHRNB4CHRNA3 | |
| SCHEMBL27129567 | 0.82 | MAPT (0.51) | SMN1; SMN2NPC1MAPTALDH1A1TP53 | |
| SCHEMBL27033517 | 0.82 | MAPT (0.51) | SMN1; SMN2NPC1MAPTALDH1A1TP53 | |
| SCHEMBL29958344 | 0.82 | MAPT (0.51) | SMN1; SMN2NPC1MAPTALDH1A1TP53 | |
| SCHEMBL30856559 | 0.81 | PIN1 (0.46) | PIN1SMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL1696052 | 0.80 | ROCK2 (0.49) | PIN1SMN1; SMN2MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6900244-B2 | Anilino liver X-receptor modulators | PHARMACIA CORPORATION (US) | 2005-05-31 | — | — | US | disclosed |
| US-20040087632-A1 | Controlling metabolism of lipids, cholesterol | PHARMACIA CORPORATION | 2004-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040087632-A1 | Controlling metabolism of lipids, cholesterol | NR1H2, NR1H3, SREBF1 | PIN1 3549/4885SMN1; SMN2 4658/4885MEN1 3557/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.