Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 15/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | THRB | P10828 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | RAD52 | P43351 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2932089 | 0.98 | FFAR1 (0.38) | FFAR1KDM4EMAPTALDH1A1THRB | |
| Hydrochloric Acid SCHEMBL6505075 | 0.85 | FFAR1 (0.37) | FFAR1KDM4EMAPTALDH1A1THRB | |
| Hydrochloric Acid SCHEMBL6096654 | 0.84 | FFAR1 (0.36) | FFAR1KDM4EMAPTALDH1A1THRB | |
| SCHEMBL2928752 | 0.84 | FFAR1 (0.38) | FFAR1KDM4EMAPTALDH1A1THRB | |
| Hydrochloric Acid SCHEMBL6496609 | 0.81 | RAD52 (0.41) | FFAR1KDM4EMAPTALDH1A1THRB | |
| SCHEMBL2926286 | 0.79 | RAD52 (0.42) | FFAR1KDM4EMAPTALDH1A1THRB | |
| SCHEMBL4890984 | 0.78 | FFAR1 (0.43) | FFAR1KDM4EMAPTALDH1A1THRB | |
| SCHEMBL78460 | 0.78 | FFAR1 (0.43) | FFAR1KDM4EMAPTALDH1A1THRB | |
| Hydrochloric Acid SCHEMBL6095710 | 0.76 | FFAR1 (0.39) | FFAR1KDM4EMAPTALDH1A1THRB | |
| SCHEMBL2879493 | 0.75 | ALDH1A1 (0.42) | FFAR1KDM4EMAPTALDH1A1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6923835-B2 | Bis-para-phenylenediamine derivatives comprising a pyrrolidyl group and use of these derivatives for dyeing keratin fibres | L'OREAL S.A. (FR) | 2005-08-02 | — | — | US | claimed |
| US-20040123401-A1 | Bis-para-phenylenediamine derivatives comprising a pyrrolidyl group and use of these derivatives for dyeing keratin fibres | L'OREAL S.A. (FR) | 2004-07-01 | — | — | US | claimed |
| US-6923835-B2 | Bis-para-phenylenediamine derivatives comprising a pyrrolidyl group and use of these derivatives for dyeing keratin fibres | L'OREAL S.A. (FR) | 2005-08-02 | — | — | US | disclosed |
| US-20040123401-A1 | Bis-para-phenylenediamine derivatives comprising a pyrrolidyl group and use of these derivatives for dyeing keratin fibres | L'OREAL S.A. (FR) | 2004-07-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040123401-A1 | Bis-para-phenylenediamine derivatives comprising a pyrrolidyl group and use of these derivatives for dyeing keratin fibres | KRT18, VIM, CDC73 | FFAR1 4768/4885KDM4E 532/4885MAPT 808/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.