Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 5/20 | 0.44 |
| ▸ | ITGAV | P06756 | 3/20 | 0.44 |
| ▸ | TYR | P14679 | 3/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.35 |
| ▸ | ACE | P12821 | 1/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ECE1 | P42892 | 1/20 | 0.33 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.33 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5208511 | 0.91 | ITGB3 (0.37) | ITGB3ITGAVTYRPPARGPDCD1 | |
| SCHEMBL6498071 | 0.89 | ITGB3 (0.44) | ITGB3ITGAVTYRPPARGITGA2B | |
| SCHEMBL3052420 | 0.88 | ITGB3 (0.44) | ITGB3ITGAVTYRPPARGITGA2B | |
| SCHEMBL6495736 | 0.86 | ITGB3 (0.44) | ITGB3ITGAVTYRPPARGITGA2B | |
| SCHEMBL3048114 | 0.84 | ITGB3 (0.44) | ITGB3ITGAVTYRPPARGITGA2B | |
| SCHEMBL3048694 | 0.80 | ITGB1 (0.50) | ITGB3ITGAVTYRITGA2BITGB1 | |
| SCHEMBL14431255 | 0.80 | ITGB1 (0.50) | ITGB3ITGAVTYRITGA2BITGB1 | |
| SCHEMBL5206753 | 0.80 | ALOX15 (0.39) | ITGB3ITGAVTYRPPARGALOX15 | |
| SCHEMBL14431276 | 0.80 | ITGB3 (0.39) | ITGB3ITGAVTYRPPARGITGA2B | |
| SCHEMBL3046466 | 0.80 | ITGB3 (0.39) | ITGB3ITGAVTYRPPARGITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6849646-B1 | Chromenone and chromanone derivatives as integrin inhibitors | MERCK PATENT GMBH (DE) | 2005-02-01 | — | — | US | disclosed |