Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESRRG | P62508 | 7/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 3/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 5/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.39 |
| ▸ | HTR3B | O95264 | 4/20 | 0.39 |
| ▸ | HTR3A | P46098 | 4/20 | 0.39 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.39 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 2/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6500637 | 0.92 | TP53 (0.43) | ESRRGCHRNA7HTR3EHTR3BHTR3A | |
| SCHEMBL6489478 | 0.87 | KDM4E (0.44) | ESRRGPTPN11PTPN2CHRNA7HTR3E | |
| SCHEMBL6503084 | 0.85 | DGAT1 (0.43) | — | |
| SCHEMBL6497200 | 0.84 | KDM4E (0.51) | ESRRGPTPN11PTPN2CHRNA7HTR3E | |
| SCHEMBL6488299 | 0.83 | ESRRG (0.55) | ESRRGPTPN11CHRNA7HTR3EHTR3B | |
| SCHEMBL6488437 | 0.83 | CHRNA7 (0.38) | ESRRGCHRNA7HTR3EHTR3BHTR3A | |
| SCHEMBL6488520 | 0.82 | CHRNA7 (0.44) | ESRRGPTPN11PTPN2CHRNA7HTR3E | |
| SCHEMBL7225979 | 0.82 | CHRNA7 (0.41) | ESRRGPTPN11PTPN2CHRNA7HTR3E | |
| SCHEMBL6489244 | 0.82 | ESRRG (0.46) | ESRRGPTPN11CHRNA7HTR3EHTR3B | |
| SCHEMBL6486663 | 0.82 | ESRRG (0.46) | ESRRGPTPN11CHRNA7HTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6919359-B2 | Azabicyclic-substituted-heteroaryl compounds for the treatment of disease | PFIZER INC (US) | 2005-07-19 | — | — | US | claimed |
| US-20030207913-A1 | Azabicyclic-substituted-heteroaryl compounds for the treatment of disease | PHARMACIA & UPJOHN COMPANY | 2003-11-06 | — | — | US | claimed |
| US-6919359-B2 | Azabicyclic-substituted-heteroaryl compounds for the treatment of disease | PFIZER INC (US) | 2005-07-19 | — | — | US | disclosed |
| US-20030207913-A1 | Azabicyclic-substituted-heteroaryl compounds for the treatment of disease | PHARMACIA & UPJOHN COMPANY | 2003-11-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030207913-A1 | Azabicyclic-substituted-heteroaryl compounds for the treatment of disease | MALT1, WFS1, NR5A1 | ESRRG 3073/4885PTPN11 1222/4885PTPN2 1913/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.