SCHEMBL6496376

SCHEMBL6496376

Cc1ccc(-c2cc(Cl)ccc2C(=O)Nc2ccc(NCCc3ccccn3)cc2)cc1

nearest known ligand 0.51

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 1/20 0.51
CTNNB1 P35222 2/20 0.50
TCF7L2 Q9NQB0 2/20 0.50
GCGR P47871 7/20 0.49
SMN1; SMN2 Q16637 2/20 0.46
L3MBTL1 Q9Y468 1/20 0.45
HTT P42858 1/20 0.45
HPGD P15428 2/20 0.44
RAB9A P51151 2/20 0.44
KDM4E B2RXH2 2/20 0.44
NPC1 O15118 1/20 0.44
GAA P10253 1/20 0.44
NR3C1 P04150 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6501757 0.95 GCGR (0.54) CNR1CTNNB1TCF7L2GCGRSMN1; SMN2
SCHEMBL6488828 0.94 CNR1 (0.51) CNR1CTNNB1TCF7L2GCGRSMN1; SMN2
SCHEMBL6497806 0.94 CNR1 (0.57) CNR1CTNNB1TCF7L2GCGRSMN1; SMN2
SCHEMBL6489227 0.93 CTNNB1 (0.48) CNR1CTNNB1TCF7L2GCGRSMN1; SMN2
SCHEMBL6497671 0.90 CNR1 (0.48) CNR1CTNNB1TCF7L2GCGRSMN1; SMN2
SCHEMBL6499473 0.90 CTNNB1 (0.53) CNR1CTNNB1TCF7L2GCGRSMN1; SMN2
SCHEMBL6498069 0.89 HDAC7 (0.49) CTNNB1TCF7L2GCGRSMN1; SMN2L3MBTL1
SCHEMBL6787263 0.89 HTT (0.49) CTNNB1TCF7L2SMN1; SMN2L3MBTL1HTT
SCHEMBL6501182 0.89 SMO (0.53) CNR1GCGRKDM4EGAANR3C1
SCHEMBL6488546 0.89 CTNNB1 (0.54) CTNNB1TCF7L2GCGRSMN1; SMN2L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050038035-A1 Heterocyclic amide compounds as apolipoprotein b inhibitors DAISO CO., LTD. (JP) 2005-02-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050038035-A1 Heterocyclic amide compounds as apolipoprotein b inhibitors APOB, APOL1, CTRB2 CNR1 102/4885CTNNB1 1793/4885TCF7L2 3727/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.