Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | CHRNA7 | P36544 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MGAM | O43451 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SI | P14410 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6496459 | 1.00 | RAB9A (0.51) | RAB9ASMN1; SMN2HSD17B10KDM4EMAPK1 | |
| Hydrochloric Acid SCHEMBL6501233 | 0.99 | RAB9A (0.50) | RAB9ASMN1; SMN2HSD17B10KDM4EMAPK1 | |
| Hydrochloric Acid SCHEMBL6501240 | 0.99 | RAB9A (0.50) | RAB9ASMN1; SMN2HSD17B10KDM4EMAPK1 | |
| SCHEMBL6501599 | 0.88 | CHRNA7 (0.49) | RAB9ASMN1; SMN2CHRNA7NPC1ALDH1A1 | |
| SCHEMBL6501606 | 0.88 | CHRNA7 (0.49) | RAB9ASMN1; SMN2CHRNA7NPC1ALDH1A1 | |
| SCHEMBL6497048 | 0.87 | ALDH1A1 (0.51) | RAB9ASMN1; SMN2KDM4EMAPK1CHRNA7 | |
| SCHEMBL6492457 | 0.87 | CHRNA7 (0.48) | RAB9ASMN1; SMN2CHRNA7NPC1ALDH1A1 | |
| SCHEMBL6492453 | 0.87 | CHRNA7 (0.48) | RAB9ASMN1; SMN2CHRNA7NPC1ALDH1A1 | |
| SCHEMBL6497050 | 0.87 | ALDH1A1 (0.51) | RAB9ASMN1; SMN2KDM4EMAPK1CHRNA7 | |
| SCHEMBL6487952 | 0.87 | RAB9A (0.54) | RAB9ASMN1; SMN2MAPK1CHRNA7NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6919359-B2 | Azabicyclic-substituted-heteroaryl compounds for the treatment of disease | PFIZER INC (US) | 2005-07-19 | — | — | US | claimed |
| US-20030207913-A1 | Azabicyclic-substituted-heteroaryl compounds for the treatment of disease | PHARMACIA & UPJOHN COMPANY | 2003-11-06 | — | — | US | claimed |
| US-6919359-B2 | Azabicyclic-substituted-heteroaryl compounds for the treatment of disease | PFIZER INC (US) | 2005-07-19 | — | — | US | disclosed |
| US-20030207913-A1 | Azabicyclic-substituted-heteroaryl compounds for the treatment of disease | PHARMACIA & UPJOHN COMPANY | 2003-11-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030207913-A1 | Azabicyclic-substituted-heteroaryl compounds for the treatment of disease | MALT1, WFS1, NR5A1 | RAB9A 1437/4885SMN1; SMN2 1751/4885HSD17B10 2073/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.