SCHEMBL6496722

SCHEMBL6496722

CCOC(=O)C(Cc1ccc(OC)c(CNC(=O)Cc2[pH]cc(OCC)c2OCC)c1)OC(C)C

nearest known ligand 0.41

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
PPARD Q03181 19/20 0.41
PPARA Q07869 19/20 0.41
PPARG P37231 17/20 0.41
POLB P06746 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6504014 0.84 PPARA (0.47) PPARDPPARAPPARGPOLB
SCHEMBL6495709 0.78 PPARA (0.44) PPARDPPARAPPARG
SCHEMBL6496923 0.77 PPARA (0.45) PPARDPPARAPPARG
SCHEMBL6502319 0.76 PPARD (0.69) PPARDPPARAPPARG
SCHEMBL4329462 0.75 ALOX15 (0.44) PPARDPPARAPPARG
SCHEMBL6506184 0.75 ALOX15 (0.46) PPARDPPARAPPARG
SCHEMBL4334796 0.75 PPARA (0.49) PPARDPPARAPPARG
SCHEMBL6503438 0.75 PPARG (0.44) PPARDPPARAPPARG
SCHEMBL6495944 0.74 PPARA (0.44) PPARDPPARAPPARG
SCHEMBL4329833 0.74 ALOX15 (0.46) PPARDPPARAPPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6884821-B1 Carboxylic acid derivatives and drugs containing the same EISAI CO., LTD. (JP) 2005-04-26 US disclosed
EP-1216980-A1 CARBOXYLIC ACID DERIVATIVES AND DRUGS CONTAINING THE SAME Eisai Co., Ltd. (JP) 2002-06-26 EP disclosed