Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.43 |
| ▸ | GSK3A | P49840 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | PRKG1 | Q13976 | 2/20 | 0.43 |
| ▸ | PRKACA | P17612 | 2/20 | 0.43 |
| ▸ | PRKX | P51817 | 2/20 | 0.43 |
| ▸ | PRKG2 | Q13237 | 2/20 | 0.43 |
| ▸ | SGK2 | Q9HBY8 | 2/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28046317 | 0.81 | ROCK2 (0.46) | MAPK1ROCK2ROCK1MAOBCLK4 | |
| SCHEMBL5135764 | 0.81 | MAPK1 (0.53) | MAPK1ROCK2ROCK1MAOBCLK4 | |
| SCHEMBL28762520 | 0.78 | MAPK1 (0.47) | MAPK1ROCK2ROCK1MAOBCLK4 | |
| SCHEMBL30245866 | 0.77 | ROCK2 (0.61) | MAPK1ROCK2ROCK1CLK4GSK3A | |
| SCHEMBL25290117 | 0.77 | ROCK2 (0.61) | MAPK1ROCK2ROCK1CLK4GSK3A | |
| SCHEMBL20628903 | 0.77 | ROCK2 (0.53) | MAPK1ROCK2ROCK1MAOBCLK4 | |
| SCHEMBL13605404 | 0.77 | MAPK1 (0.58) | MAPK1ROCK2ROCK1MAOBCLK4 | |
| SCHEMBL23022915 | 0.75 | ROCK2 (0.56) | MAPK1ROCK2ROCK1CLK4RPS6KB1 | |
| SCHEMBL10210705 | 0.74 | MAPK1 (0.62) | MAPK1ROCK2ROCK1MAOBCLK4 | |
| SCHEMBL269208 | 0.74 | MAPK1 (0.55) | MAPK1ROCK2ROCK1MAOBCLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |