Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | NEK2 | P51955 | 1/20 | 0.53 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.52 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | RXRA | P19793 | 1/20 | 0.48 |
| ▸ | RXRB | P28702 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | RARA | P10276 | 1/20 | 0.47 |
| ▸ | RARB | P10826 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2769244 | 0.91 | ADRB1 (0.55) | KDM4ESMN1; SMN2HSD17B10MEN1KMT2A | |
| SCHEMBL4600782 | 0.90 | PTPN11 (0.54) | KDM4ESMN1; SMN2HSD17B10MEN1KMT2A | |
| SCHEMBL6498950 | 0.88 | ADRB3 (0.60) | KDM4ESMN1; SMN2HSD17B10NEK2ADRB1 | |
| SCHEMBL1546492 | 0.87 | KDM4E (0.57) | KDM4ESMN1; SMN2HSD17B10NEK2ALDH1A1 | |
| SCHEMBL6505249 | 0.85 | ADRB1 (0.52) | KDM4EHSD17B10MEN1KMT2ANEK2 | |
| SCHEMBL4844621 | 0.80 | KDM4E (0.70) | KDM4ESMN1; SMN2HSD17B10MEN1KMT2A | |
| SCHEMBL28515025 | 0.80 | TSHR (0.50) | KDM4ESMN1; SMN2KMT2ALMNAMAPT | |
| SCHEMBL1881271 | 0.80 | KDM4E (0.59) | KDM4ESMN1; SMN2HSD17B10MEN1KMT2A | |
| SCHEMBL3903917 | 0.80 | KDM4E (0.60) | KDM4ESMN1; SMN2HSD17B10MEN1KMT2A | |
| SCHEMBL4603254 | 0.79 | TSHR (0.59) | KDM4ESMN1; SMN2HSD17B10MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6884821-B1 | Carboxylic acid derivatives and drugs containing the same | EISAI CO., LTD. (JP) | 2005-04-26 | — | — | US | disclosed |
| EP-1216980-A1 | CARBOXYLIC ACID DERIVATIVES AND DRUGS CONTAINING THE SAME | Eisai Co., Ltd. (JP) | 2002-06-26 | — | — | EP | disclosed |