Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.54 |
| ▸ | TACR1 | P25103 | 1/20 | 0.51 |
| ▸ | CTRB1 | P17538 | 3/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | CTSK | P43235 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.46 |
| ▸ | ITGAV | P06756 | 2/20 | 0.46 |
| ▸ | KYNU | Q16719 | 1/20 | 0.46 |
| ▸ | CTSG | P08311 | 1/20 | 0.45 |
| ▸ | ELANE | P08246 | 2/20 | 0.45 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.45 |
| ▸ | CTSL | P07711 | 2/20 | 0.45 |
| ▸ | CTSS | P25774 | 2/20 | 0.45 |
| ▸ | CTSB | P07858 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8296973 | 1.00 | SYK (0.54) | SYKTACR1CTRB1CASP1CTSK | |
| SCHEMBL6497581 | 0.92 | ALDH1A1 (0.52) | SYKCTRB1CTSKMAPTRAB9A | |
| SCHEMBL8298823 | 0.92 | ALDH1A1 (0.52) | SYKCTRB1CTSKMAPTRAB9A | |
| SCHEMBL6495244 | 0.90 | NPC1 (0.49) | SYKCTSKRAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL8297484 | 0.90 | NPC1 (0.49) | SYKCTSKRAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL10966776 | 0.86 | CTRB1 (0.61) | SYKCTRB1CASP1CTSKKYNU | |
| SCHEMBL6500389 | 0.85 | HPGD (0.53) | SYKCTRB1CTSKALDH1A1 | |
| SCHEMBL8296983 | 0.85 | HPGD (0.53) | SYKCTRB1CTSKALDH1A1 | |
| SCHEMBL13955194 | 0.85 | SYK (0.53) | SYKCTRB1CASP1CTSKITGB3 | |
| SCHEMBL30946052 | 0.84 | SYK (0.77) | SYKCTRB1CTSKMAPTCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | disclosed |