Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.50 |
| ▸ | SYK | P43405 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.46 |
| ▸ | CTSK | P43235 | 1/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6500389 | 1.00 | HPGD (0.53) | HPGDTP53GLAKCNA3SYK | |
| SCHEMBL8296973 | 0.85 | SYK (0.54) | SYKCTRB1CTSKALDH1A1 | |
| SCHEMBL6497240 | 0.85 | SYK (0.54) | SYKCTRB1CTSKALDH1A1 | |
| SCHEMBL8298823 | 0.83 | ALDH1A1 (0.52) | TP53SYKCTRB1CTSKALDH1A1 | |
| SCHEMBL6497581 | 0.83 | ALDH1A1 (0.52) | TP53SYKCTRB1CTSKALDH1A1 | |
| SCHEMBL10966776 | 0.81 | CTRB1 (0.61) | SYKCTRB1CTSKPOLBALDH1A1 | |
| SCHEMBL8297484 | 0.81 | NPC1 (0.49) | HPGDSYKCTSK | |
| SCHEMBL6495244 | 0.81 | NPC1 (0.49) | HPGDSYKCTSK | |
| SCHEMBL13955194 | 0.80 | SYK (0.53) | SYKLMNACTRB1CTSKALDH1A1 | |
| SCHEMBL30946052 | 0.79 | SYK (0.77) | SYKCTRB1CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | disclosed |