Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.57 |
| ▸ | RAB9A | P51151 | 5/20 | 0.57 |
| ▸ | NPC1 | O15118 | 4/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.57 |
| ▸ | GFER | P55789 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7495727 | 0.84 | POLB (0.69) | POLBLMNAKDM4ESMN1; SMN2RAB9A | |
| SCHEMBL31490713 | 0.82 | POLB (0.59) | POLBLMNAKDM4ESMN1; SMN2RAB9A | |
| SCHEMBL4252143 | 0.79 | PARP1 (0.57) | POLBLMNAKDM4ESMN1; SMN2RAB9A | |
| SCHEMBL893991 | 0.79 | PARP1 (0.57) | POLBLMNAKDM4ESMN1; SMN2RAB9A | |
| SCHEMBL13702275 | 0.79 | KDM4E (0.62) | POLBLMNAKDM4ESMN1; SMN2RAB9A | |
| SCHEMBL13701704 | 0.79 | LMNA (0.56) | POLBLMNAKDM4ESMN1; SMN2RAB9A | |
| SCHEMBL13753398 | 0.79 | KDM4E (0.58) | POLBLMNAKDM4ESMN1; SMN2RAB9A | |
| SCHEMBL7056764 | 0.79 | HPGD (0.59) | POLBLMNAKDM4ESMN1; SMN2RAB9A | |
| SCHEMBL8970557 | 0.78 | KCNK3 (0.70) | POLBKDM4ESMN1; SMN2RAB9ANPC1 | |
| Hydrochloric Acid SCHEMBL3862436 | 0.78 | PARP1 (0.55) | POLBLMNAKDM4ESMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | claimed |
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | disclosed |