Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 3/20 | 0.77 |
| ▸ | SLC6A4 | P31645 | 14/20 | 0.70 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.58 |
| ▸ | TSHR | P16473 | 3/20 | 0.58 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.58 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.58 |
| ▸ | HTR2A | P28223 | 2/20 | 0.58 |
| ▸ | HTR2C | P28335 | 2/20 | 0.58 |
| ▸ | HRH1 | P35367 | 2/20 | 0.58 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.58 |
| ▸ | DRD3 | P35462 | 2/20 | 0.58 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.58 |
| ▸ | HTR2B | P41595 | 2/20 | 0.58 |
| ▸ | KLF10 | Q13118 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6497746 | 1.00 | NOS2 (0.77) | NOS2SLC6A4SLC6A2CYP2D6CYP1A2 | |
| Fumaric Acid SCHEMBL6501358 | 0.91 | NOS2 (0.80) | NOS2SLC6A4SLC6A2CYP2D6CYP1A2 | |
| Fumaric Acid SCHEMBL6501362 | 0.91 | NOS2 (0.80) | NOS2SLC6A4SLC6A2CYP2D6CYP1A2 | |
| SCHEMBL6492848 | 0.87 | NOS2 (1.00) | NOS2SLC6A4SLC6A2CYP2D6CYP1A2 | |
| SCHEMBL6492851 | 0.87 | NOS2 (1.00) | NOS2SLC6A4SLC6A2CYP2D6CYP1A2 | |
| SCHEMBL7055188 | 0.84 | NOS2 (0.75) | NOS2SLC6A4SLC6A2CYP2D6CYP1A2 | |
| Hydrochloric Acid SCHEMBL9293022 | 0.82 | NOS2 (0.73) | NOS2SLC6A4SLC6A2CYP2D6CYP1A2 | |
| SCHEMBL6504695 | 0.81 | SLC6A4 (0.75) | NOS2SLC6A4SLC6A2CYP2D6CYP1A2 | |
| SCHEMBL6502159 | 0.81 | NOS2 (0.72) | NOS2SLC6A4SLC6A2CYP2D6CYP1A2 | |
| SCHEMBL6502153 | 0.81 | NOS2 (0.72) | NOS2SLC6A4SLC6A2CYP2D6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6887871-B2 | Use of phenylheteroakylamine derivatives | ASTRAZENECA AB (SE) | 2005-05-03 | — | — | US | disclosed |
| EP-1263711-B1 | NOVEL USE OF PHENYLHETEROALKYLAMINE DERIVATIVES | ASTRAZENECA AB (SE) | 2004-12-15 | — | — | EP | disclosed |
| US-20030158185-A1 | Novel use of phenylheteroakylamine derivatives | ASTRAZENECA AB (SE) | 2003-08-21 | — | — | US | disclosed |
| EP-1263711-A1 | NOVEL USE OF PHENYLHETEROALKYLAMINE DERIVATIVES | AstraZeneca AB (SE) | 2002-12-11 | — | — | EP | disclosed |
| WO-2001062704-A1 | NOVEL USE OF PHENYLHETEROALKYLAMINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-08-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030158185-A1 | Novel use of phenylheteroakylamine derivatives | NOS1, XDH, NOS2 | NOS2 3/4885SLC6A4 2468/4885SLC6A2 1776/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.