Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 9/20 | 0.66 |
| ▸ | ESR1 | P03372 | 8/20 | 0.61 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.61 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CA3 | P07451 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | CA6 | P23280 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 2/20 | 0.42 |
| ▸ | USP7 | Q93009 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2211186 | 0.88 | ESR2 (0.55) | ESR2ESR1HSD17B1FGFR1ALDH1A1 | |
| SCHEMBL439874 | 0.87 | ESR2 (0.76) | ESR2ESR1HSD17B1FGFR1HSD17B10 | |
| SCHEMBL29738442 | 0.87 | ESR2 (0.76) | ESR2ESR1HSD17B1FGFR1HSD17B10 | |
| SCHEMBL2718119 | 0.85 | ESR2 (0.73) | ESR2ESR1HSD17B1FGFR1HSD17B10 | |
| SCHEMBL27479510 | 0.84 | CASP1 (0.47) | ESR2ESR1HSD17B1ALDH1A1CA3 | |
| SCHEMBL99566 | 0.83 | ALDH1A1 (0.54) | ESR2ESR1HSD17B1ALDH1A1CYP3A4 | |
| SCHEMBL8953996 | 0.81 | ALDH1A1 (0.52) | ESR2ESR1HSD17B1ALDH1A1CYP3A4 | |
| SCHEMBL8953943 | 0.81 | CYP3A4 (0.50) | ESR2ESR1HSD17B1ALDH1A1CYP3A4 | |
| Methane SCHEMBL28805939 | 0.81 | ALDH1A1 (0.52) | ESR2ESR1HSD17B1ALDH1A1CYP3A4 | |
| SCHEMBL7137793 | 0.81 | ALOX5 (0.61) | ESR2ESR1ALDH1A1CA3CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050065195-A1 | Oxadiazolyl-biphenylcarboxamides and their use as p38 kinase inhibitors | GLAXO GROUP LIMITED (GB) | 2005-03-24 | — | — | US | disclosed |
| US-4010279-A | BIPHENYLOXY DERIVATIVES AND ANTIHYPERLIPIDEMIC USE | BOEHRINGER INGELHEIM GMBH (DT) | 1977-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050065195-A1 | Oxadiazolyl-biphenylcarboxamides and their use as p38 kinase inhibitors | MAPK3, MAPK1, MAPKAPK3 | ESR2 1838/4885ESR1 1743/4885HSD17B1 1042/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.