Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 11/20 | 0.76 |
| ▸ | OPRL1 | P41146 | 10/20 | 0.76 |
| ▸ | OPRM1 | P35372 | 10/20 | 0.76 |
| ▸ | OPRD1 | P41143 | 9/20 | 0.76 |
| ▸ | DRD2 | P14416 | 4/20 | 0.76 |
| ▸ | DRD3 | P35462 | 4/20 | 0.76 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.76 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.76 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.76 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.76 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.76 |
| ▸ | HRH1 | P35367 | 2/20 | 0.76 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.76 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.76 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.76 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.76 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.76 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.76 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.76 |
| ▸ | CCR8 | P51685 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6496857 | 0.90 | OPRK1 (0.76) | OPRK1OPRL1OPRM1OPRD1DRD2 | |
| SCHEMBL6506316 | 0.87 | OPRK1 (1.00) | OPRK1OPRL1OPRM1OPRD1DRD2 | |
| SCHEMBL6505331 | 0.86 | OPRL1 (0.80) | OPRK1OPRL1OPRM1OPRD1DRD2 | |
| SCHEMBL6506309 | 0.86 | OPRL1 (0.80) | OPRK1OPRL1OPRM1OPRD1DRD2 | |
| SCHEMBL6508685 | 0.86 | OPRK1 (0.80) | OPRK1OPRL1OPRM1OPRD1DRD2 | |
| SCHEMBL6507957 | 0.86 | OPRL1 (0.79) | OPRK1OPRL1OPRM1OPRD1DRD2 | |
| SCHEMBL6505717 | 0.86 | OPRK1 (0.79) | OPRK1OPRL1OPRM1OPRD1DRD2 | |
| SCHEMBL6498210 | 0.84 | OPRL1 (0.76) | OPRK1OPRL1OPRM1OPRD1DRD2 | |
| SCHEMBL6505480 | 0.84 | OPRK1 (0.76) | OPRK1OPRL1OPRM1OPRD1DRD2 | |
| SCHEMBL6496724 | 0.84 | OPRK1 (0.76) | OPRK1OPRL1OPRM1OPRD1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050143372-A1 | Compounds, pharmaceutical compositions and methods of use therefor | MILLENNIUM PHARMACEUTICALS, INC. | 2005-06-30 | — | — | US | disclosed |
| WO-2003037271-A2 | COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREFOR | MILLENNIUM PHARMACEUTICALS,INC. (US) | 2003-05-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050143372-A1 | Compounds, pharmaceutical compositions and methods of use therefor | CCR8, CCL11, CCR5 | OPRK1 246/4885OPRL1 140/4885OPRM1 494/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.