Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.44 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.44 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6506024 | 0.91 | MAPT (0.47) | HPGDLMNAALDH1A1TSHRPKM | |
| SCHEMBL6505651 | 0.85 | HPGD (0.49) | HPGDLMNAALDH1A1KDM4ETSHR | |
| SCHEMBL6503133 | 0.83 | LMNA (0.56) | HPGDLMNAALDH1A1TSHRMAPT | |
| SCHEMBL6495951 | 0.79 | HPGD (0.53) | HPGDLMNAALDH1A1KDM4EGAA | |
| SCHEMBL6498811 | 0.77 | HPGD (0.48) | HPGDLMNAALDH1A1KDM4EHSD17B10 | |
| SCHEMBL6494246 | 0.76 | LMNA (0.44) | HPGDLMNAALDH1A1TSHRPKM | |
| SCHEMBL6374942 | 0.76 | KMT2A (0.51) | HPGDALDH1A1KDM4EPKMROCK2 | |
| SCHEMBL305177 | 0.76 | PTPN1 (0.49) | HPGDLMNAKDM4ECA2ROCK2 | |
| SCHEMBL6382478 | 0.76 | CYP1A2 (0.62) | HPGDPOLBALDH1A1KDM4ETSHR | |
| SCHEMBL6496044 | 0.76 | PTPN1 (0.47) | LMNAALDH1A1CA2PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6884821-B1 | Carboxylic acid derivatives and drugs containing the same | EISAI CO., LTD. (JP) | 2005-04-26 | — | — | US | disclosed |
| EP-1216980-A1 | CARBOXYLIC ACID DERIVATIVES AND DRUGS CONTAINING THE SAME | Eisai Co., Ltd. (JP) | 2002-06-26 | — | — | EP | disclosed |