Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.46 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6494246 | 0.91 | LMNA (0.44) | HPGDLMNAALDH1A1CA2PKM | |
| SCHEMBL6498700 | 0.85 | HPGD (0.47) | HPGDLMNAALDH1A1CA2GAA | |
| SCHEMBL6495951 | 0.84 | HPGD (0.53) | HPGDLMNAALDH1A1CA2GAA | |
| SCHEMBL6501926 | 0.84 | KMT2A (0.45) | HPGDLMNAALDH1A1CA2PKM | |
| SCHEMBL6498811 | 0.82 | HPGD (0.48) | HPGDLMNAALDH1A1CA2GAA | |
| SCHEMBL6497335 | 0.80 | MEN1 (0.53) | HPGDLMNAALDH1A1CA2GAA | |
| SCHEMBL6506747 | 0.77 | CA2 (0.48) | HPGDLMNAALDH1A1CA2KDM4E | |
| SCHEMBL6504802 | 0.77 | HTT (0.55) | HPGDLMNACA2GAAHTT | |
| SCHEMBL6503028 | 0.77 | PDE10A (0.47) | HPGDLMNAALDH1A1CA2GAA | |
| SCHEMBL13846776 | 0.77 | CA2 (0.69) | LMNAALDH1A1CA2GAAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6884821-B1 | Carboxylic acid derivatives and drugs containing the same | EISAI CO., LTD. (JP) | 2005-04-26 | — | — | US | disclosed |
| EP-1216980-A1 | CARBOXYLIC ACID DERIVATIVES AND DRUGS CONTAINING THE SAME | Eisai Co., Ltd. (JP) | 2002-06-26 | — | — | EP | disclosed |