Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 4/20 | 0.41 |
| ▸ | MPC2 | O95563 | 2/20 | 0.41 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6503133 | 0.92 | LMNA (0.56) | MAPTLMNAROCK2ROCK1PDE10A | |
| SCHEMBL6498700 | 0.91 | HPGD (0.47) | MAPTLMNAROCK2ROCK1HPGD | |
| SCHEMBL6494246 | 0.85 | LMNA (0.44) | MAPTLMNAROCK2ROCK1PDE10A | |
| SCHEMBL6501926 | 0.84 | KMT2A (0.45) | MAPTLMNAROCK2ROCK1PDE10A | |
| SCHEMBL30990019 | 0.78 | LMNA (0.57) | MAPTLMNAROCK2ROCK1PDE10A | |
| SCHEMBL6506747 | 0.78 | CA2 (0.48) | MAPTLMNAROCK2ROCK1PDE10A | |
| SCHEMBL6503028 | 0.78 | PDE10A (0.47) | MAPTLMNAROCK2ROCK1PDE10A | |
| SCHEMBL30989879 | 0.77 | LMNA (0.55) | MAPTLMNAROCK2ROCK1PDE10A | |
| SCHEMBL6505651 | 0.76 | HPGD (0.49) | MAPTLMNAPDE10AKMT2AMEN1 | |
| SCHEMBL6495876 | 0.74 | HPGD (0.44) | MAPTLMNAPDE10APPARGKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6884821-B1 | Carboxylic acid derivatives and drugs containing the same | EISAI CO., LTD. (JP) | 2005-04-26 | — | — | US | disclosed |
| EP-1216980-A1 | CARBOXYLIC ACID DERIVATIVES AND DRUGS CONTAINING THE SAME | Eisai Co., Ltd. (JP) | 2002-06-26 | — | — | EP | disclosed |