SCHEMBL6499535

SCHEMBL6499535

COC(=O)C(N)CN(C)C(=O)c1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 1/20 0.47
HDAC6 Q9UBN7 1/20 0.47
KMT2A Q03164 4/20 0.46
LTA4H P09960 1/20 0.45
KIF11 P52732 1/20 0.44
MEN1 O00255 2/20 0.43
PLA2G1B P04054 1/20 0.43
HTT P42858 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
ATG4B Q9Y4P1 1/20 0.43
SLC7A5 Q01650 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.41
TACR1 P25103 1/20 0.41
F2 P00734 1/20 0.41
FNTA P49354 2/20 0.41
FNTB P49356 2/20 0.41
TSHR P16473 1/20 0.41
GAA P10253 1/20 0.40
ALDH1A1 P00352 1/20 0.39
LMNA P02545 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6499537 0.98 HDAC1 (0.46) HDAC1HDAC6KMT2ALTA4HKIF11
SCHEMBL11248977 0.79 KMT2A (0.47) HDAC1HDAC6KMT2AMEN1HTT
SCHEMBL2703155 0.76 LTA4H (0.51) HDAC1HDAC6KMT2ALTA4HKIF11
SCHEMBL2703603 0.76 LTA4H (0.51) HDAC1HDAC6KMT2ALTA4HKIF11
SCHEMBL1003650 0.75 NAMPT (0.55) HDAC1HDAC6KMT2AMEN1HTT
SCHEMBL2620474 0.75 SMN1; SMN2 (0.53) KMT2AKIF11SMN1; SMN2TSHRGAA
SCHEMBL20121319 0.75 SMN1; SMN2 (0.53) KMT2AKIF11SMN1; SMN2TSHRGAA
SCHEMBL18651715 0.74 MEN1 (0.43) HDAC1HDAC6KMT2AMEN1HTT
Hydrochloric Acid SCHEMBL3867992 0.74 SMN1; SMN2 (0.51) KMT2AKIF11SMN1; SMN2TSHRGAA
Hydrochloric Acid SCHEMBL6500931 0.74 SMN1; SMN2 (0.51) KMT2AKIF11SMN1; SMN2TSHRGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005016883-A2 ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF ICOS CORPORATION (US) 2005-02-24 WO disclosed