Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 4/20 | 0.58 |
| ▸ | NOTUM | Q6P988 | 9/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | SERPINE1 | P05121 | 4/20 | 0.47 |
| ▸ | IDH2 | P48735 | 1/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6498968 | 0.91 | NOTUM (0.62) | FFAR4NOTUMPOLBCYP2C9CYP2C19 | |
| SCHEMBL5801907 | 0.86 | NOTUM (0.57) | FFAR4NOTUMCYP2C19PDK2 | |
| SCHEMBL6501545 | 0.81 | LGMN (0.52) | FFAR4POLBPDK2 | |
| SCHEMBL30173256 | 0.80 | NOTUM (0.85) | NOTUMPOLBSERPINE1IDH2 | |
| SCHEMBL4334462 | 0.80 | NOTUM (0.85) | NOTUMPOLBSERPINE1IDH2 | |
| SCHEMBL5376583 | 0.79 | FFAR4 (0.54) | FFAR4POLB | |
| SCHEMBL2071701 | 0.79 | NOTUM (0.83) | FFAR4NOTUMPOLBCYP2C9CYP2C19 | |
| SCHEMBL2935259 | 0.78 | NOTUM (0.68) | NOTUMPOLBCYP2C9CYP2C19 | |
| SCHEMBL1410379 | 0.77 | FFAR4 (0.48) | FFAR4NOTUMIDH2 | |
| SCHEMBL28647219 | 0.75 | FFAR4 (0.50) | FFAR4POLBCYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005019200-A2 | ARYL PIPERIDINE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-03-03 | — | — | WO | disclosed |