Sugi Predict

Sugi Predict / Compounds / SCHEMBL2071701

SCHEMBL2071701

SCHEMBL2071701

O=C(O)C1CCN(c2ccc(C(F)(F)F)cc2)CC1

nearest known ligand 0.83

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ NOTUM Q6P988 10/20 0.83
▸ SERPINE1 P05121 1/20 0.62
▸ DEGS1 O15121 1/20 0.56
▸ CA12 O43570 1/20 0.55
▸ CA2 P00918 1/20 0.55
▸ CA9 Q16790 1/20 0.55
▸ POLB P06746 1/20 0.53
▸ CYP2C9 P11712 1/20 0.53
▸ CYP2C19 P33261 1/20 0.53
▸ AKR1C3 P42330 2/20 0.52
▸ FFAR4 Q5NUL3 1/20 0.52
▸ CHRM2 P08172 1/20 0.52
▸ PDK2 Q15119 1/20 0.51
▸ IDH2 P48735 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16684703 0.91 NOTUM (1.00) NOTUMSERPINE1DEGS1
SCHEMBL12508733 0.88 NOTUM (0.69) NOTUMSERPINE1DEGS1CA12CA2
SCHEMBL21180892 0.86 NOTUM (0.67) NOTUMSERPINE1DEGS1CA12CA2
SCHEMBL5790870 0.86 NOTUM (0.67) NOTUMSERPINE1DEGS1CA12CA2
SCHEMBL985184 0.84 NOTUM (0.60) NOTUMSERPINE1CYP2C19AKR1C3FFAR4
SCHEMBL6498968 0.84 NOTUM (0.62) NOTUMSERPINE1POLBCYP2C9CYP2C19
SCHEMBL4334462 0.82 NOTUM (0.85) NOTUMSERPINE1POLBIDH2
SCHEMBL30173256 0.82 NOTUM (0.85) NOTUMSERPINE1POLBIDH2
SCHEMBL12419723 0.82 NOTUM (0.62) NOTUMSERPINE1DEGS1CA12CA2
SCHEMBL21542280 0.82 NOTUM (0.62) NOTUMSERPINE1DEGS1CA12CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250340557-A1 PYRIMIDINE DERIVATIVE ASKA PHARMACEUTICAL CO., LTD. (JP) 2025-11-06 — — US disclosed
EP-4553068-A1 PYRIMIDINE DERIVATIVES ASKA Pharmaceutical Co., Ltd. (JP) 2025-05-14 — — EP disclosed
CN-119497709-A Pyrimidine derivatives ASKA 制药株式会社 2025-02-21 — — CN disclosed
CN-118496156-A Compounds with STING inhibition activity, preparation method and application thereof 中国科学院上海药物研究所 2024-08-16 — — CN disclosed
WO-2024010015-A1 PYRIMIDINE DERIVATIVES あすか製薬株式会社 2024-01-11 — — WO disclosed
US-11771684-B2 Inhibitors of dihydroceramide desaturase for treating disease CENTAURUS THERAPEUTICS (US) 2023-10-03 — — US disclosed
US-11771684-B2 Inhibitors of dihydroceramide desaturase for treating disease CENTAURUS THERAPEUTICS (US) 2023-10-03 — — US disclosed
US-20230089247-A1 NOVEL COMPOUNDS SUITABLE FOR THE TREATMENT OF DYSLIPIDEMIA ZYDUS LIFESCIENCES LIMITED (IN) 2023-03-23 — — US disclosed
EP-4081509-A1 NOVEL COMPOUNDS SUITABLE FOR THE TREATMENT OF DYSLIPIDEMIA Zydus Lifesciences Limited (IN) 2022-11-02 — — EP disclosed
CN-114901640-A Novel compounds useful for the treatment of dyslipidemia 兹杜斯生命科学有限公司 2022-08-12 — — CN disclosed
US-20090062261-A1 NITROGEN-CONTAINING HETEROCYCLE DERIVATIVES SUBSTITUTED WITH CYCLIC GROUP SHIONOGI & CO., LTD. (JP) 2009-03-05 — — US disclosed
EP-1670761-B1 TETRAHYDRO-NAPHTHALENE AND UREA DERIVATIVES XENTION LTD (GB) 2009-01-28 — — EP disclosed
US-20070167458-A1 Tetrahydro-naphthalene and urea derivatives BAYER HEALTHCARE AG (DE) 2007-07-19 — — US disclosed
US-20070167458-A1 Tetrahydro-naphthalene and urea derivatives BAYER HEALTHCARE AG (DE) 2007-07-19 — — US disclosed
US-20060116368-A1 4-Piperidinecarboxamide modulators of vanilloid VR1 receptor JANSSEN PHARMACEUTICA N.V. (BE) 2006-06-01 — — US disclosed
WO-2006058338-A2 4 - PIPERIDINECARBOXAMIDE DERIVATIVES AS MODULATORS OF VANILLOID VR1 RECEPTOR JANSSEN PHARMACEUTICA N.V. (BE) 2006-06-01 — — WO disclosed
EP-1660481-A1 PIPERIDINE/CYCLOHEXANE CARBOXAMIDE DERIVATIVES FOR USE AS VANILLOID RECEPTOR MODULATORS GLAXO GROUP LIMITED (GB) 2006-05-31 — — EP disclosed
WO-2006002956-A1 PIPERIDINE DERIVATIVES AND THEIR USE AS GLYCINE TRANSPORTER INHIBITORS GLAXO GROUP LIMITED (GB) 2006-01-12 — — WO disclosed
WO-2005058885-A2 PIPERIDINE DERIVATIVES AND THEIR USE AS GLYCINE TRANSPORTER INHIBITORS GLAXO GROUP LIMITED (GB) 2005-06-30 — — WO disclosed
WO-2005016915-A1 PIPERIDINE/CYCLOHEXANE CARBOXAMIDE DERIVATIVES FOR USE AS VANILLOID RECEPTOR MODULATORS GLAXO GROUP LIMITED (GB) 2005-02-24 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11771684-B2 Inhibitors of dihydroceramide desaturase for treating disease CERS2, DEGS1, SMPD1 NOTUM 315/4885SERPINE1 290/4885DEGS1 2/4885
US-20090062261-A1 NITROGEN-CONTAINING HETEROCYCLE DERIVATIVES SUBSTITUTED WITH CYCLIC GROUP NR4A1, NR0B2, NR0B1 NOTUM 3462/4885SERPINE1 4506/4885DEGS1 2687/4885
US-20070167458-A1 Tetrahydro-naphthalene and urea derivatives NQO2, UGT1A4, CYP4B1 NOTUM 3934/4885SERPINE1 1995/4885DEGS1 2377/4885
US-20230089247-A1 NOVEL COMPOUNDS SUITABLE FOR THE TREATMENT OF DYSLIPIDEMIA PCSK9, CETP, LCAT NOTUM 149/4885SERPINE1 712/4885DEGS1 326/4885
US-20250340557-A1 PYRIMIDINE DERIVATIVE PTGES, PTGS1, PTGIS NOTUM 2160/4885SERPINE1 467/4885DEGS1 2619/4885
US-20060116368-A1 4-Piperidinecarboxamide modulators of vanilloid VR1 receptor VDAC1, TRPV1, HVCN1 NOTUM 3548/4885SERPINE1 3323/4885DEGS1 1714/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.