Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LGMN | Q99538 | 2/20 | 0.52 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.51 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6528497 | 0.93 | LGMN (0.56) | LGMNFFAR4PDK2MAPTALDH1A1 | |
| SCHEMBL6506137 | 0.83 | NOTUM (0.61) | LGMNPDK2MAPTALDH1A1KDM4E | |
| SCHEMBL2167020 | 0.83 | MAPT (0.64) | LGMNPDK2MAPTALDH1A1KDM4E | |
| SCHEMBL16648623 | 0.82 | LGMN (0.51) | LGMNPDK2MAPTALDH1A1KDM4E | |
| SCHEMBL6499990 | 0.81 | FFAR4 (0.58) | FFAR4PDK2POLB | |
| SCHEMBL29838655 | 0.79 | LGMN (0.61) | LGMNPDK2MAPTALDH1A1TDP1 | |
| SCHEMBL1749330 | 0.78 | MAPT (0.68) | LGMNPDK2MAPTALDH1A1TDP1 | |
| SCHEMBL38658169 | 0.78 | LGMN (0.62) | LGMNPDK2MAPTALDH1A1TDP1 | |
| SCHEMBL4134420 | 0.77 | MAPT (0.57) | LGMNPDK2MAPTALDH1A1KDM4E | |
| SCHEMBL6501131 | 0.77 | LGMN (0.61) | LGMNMAPTALDH1A1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005019200-A2 | ARYL PIPERIDINE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-03-03 | — | — | WO | disclosed |