Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6500038 | 1.00 | GAA (0.61) | GAANPSR1MEN1KMT2AHTT | |
| SCHEMBL7211590 | 0.95 | GAA (0.56) | GAANPSR1MEN1KMT2AHTT | |
| SCHEMBL7211592 | 0.95 | GAA (0.56) | GAANPSR1MEN1KMT2AHTT | |
| SCHEMBL2584550 | 0.85 | CHRM2 (0.47) | GAANPSR1MEN1KMT2AHTT | |
| SCHEMBL24700590 | 0.85 | CHRM2 (0.49) | MEN1KMT2ACYP2C19ALDH1A1KDM4E | |
| SCHEMBL12345392 | 0.85 | CHRM2 (0.49) | MEN1KMT2ACYP2C19ALDH1A1KDM4E | |
| SCHEMBL7221812 | 0.84 | NPSR1 (0.47) | GAANPSR1MEN1KMT2AHTT | |
| SCHEMBL5938908 | 0.81 | GRIN2B (0.54) | GAANPSR1MEN1KMT2AHTT | |
| SCHEMBL31734922 | 0.81 | CHRM2 (0.45) | GAANPSR1MEN1KMT2AHTT | |
| SCHEMBL8208993 | 0.81 | CHRM2 (0.45) | GAANPSR1MEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6964972-B2 | 8-Azabicyclo(3,2,1)oct-2 ene and octane derivatives as cholinergic ligands at nicotinic ACh receptors | NEUROSEARCH A/S (DK) | 2005-11-15 | — | — | US | disclosed |
| EP-0984965-B1 | 8-AZABICYCLO(3,2,1)OCT-2-ENE AND OCTANE DERIVATIVES AS CHOLINERGIC LIGANDS AT NICOTINIC ACH RECEPTORS | NEUROSEARCH AS (DK) | 2004-05-19 | — | — | EP | disclosed |
| US-20040019207-A1 | Amines such as 8-Benzyl-3-(3-pyridyl)-8-azabicyclo(3.2.1) oct-2-ene, that bind to nicotinic acetocholine receptors, used for prophylaxis of nervous system disorders, as analgesis, antiinflammatory agents and drug abuse | NEUROSEARCH A/S | 2004-01-29 | — | — | US | disclosed |
| US-6645977-B1 | Amines such as 8-Methyl-3-(3-pyridyl)-8-azabicyclo(3.2.1)-oct-2-ene, administered to humans or animals for prophylaxis of drug abuse or drug dependence | NEUROSEARCH A/S (DK) | 2003-11-11 | — | — | US | disclosed |
| EP-0984965-A1 | 8-AZABICYCLO(3,2,1)OCT-2-ENE AND OCTANE DERIVATIVES AS CHOLINERGIC LIGANDS AT NICOTINIC ACH RECEPTORS | NEUROSEARCH A/S (DK) | 2000-03-15 | — | — | EP | disclosed |
| EP-0971918-A1 | BICYCLIC AMINE DERIVATIVES | ZENECA LIMITED (GB) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998054181-A1 | 8-AZABICYCLO(3,2,1)OCT-2-ENE AND OCTANE DERIVATIVES AS CHOLINERGIC LIGANDS AT NICOTINIC ACH RECEPTORS | NEUROSEARCH A/S (DK) | 1998-12-03 | — | — | WO | disclosed |
| WO-1998046600-A1 | BICYCLIC AMINE DERIVATIVES | ZENECA LIMITED (GB) | 1998-10-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040019207-A1 | Amines such as 8-Benzyl-3-(3-pyridyl)-8-azabicyclo(3.2.1) oct-2-ene, that bind to nicotinic acetocholine receptors, used for prophylaxis of nervous system disorders, as analgesis, antiinflammatory agents and drug abuse | OPRL1, OPRK1, OPRM1 | GAA 4391/4885NPSR1 189/4885MEN1 4860/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.