Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PREP | P48147 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.37 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31734922 | 1.00 | CHRM2 (0.45) | CHRM2CHRM1CHRM3CYP2C19ALDH1A1 | |
| SCHEMBL6500041 | 0.81 | GAA (0.61) | CHRM2CHRM1CHRM3CYP2C19ALDH1A1 | |
| SCHEMBL6500038 | 0.81 | GAA (0.61) | CHRM2CHRM1CHRM3CYP2C19ALDH1A1 | |
| SCHEMBL23949975 | 0.80 | POLB (0.42) | POLBHTTMEN1KMT2A | |
| SCHEMBL2584550 | 0.80 | CHRM2 (0.47) | CHRM2CHRM1CHRM3CYP2C19ALDH1A1 | |
| SCHEMBL30257554 | 0.80 | POLB (0.42) | POLBHTTMEN1KMT2A | |
| SCHEMBL12345392 | 0.79 | CHRM2 (0.49) | CHRM2CHRM1CHRM3CYP2C19ALDH1A1 | |
| SCHEMBL24700590 | 0.79 | CHRM2 (0.49) | CHRM2CHRM1CHRM3CYP2C19ALDH1A1 | |
| SCHEMBL24154704 | 0.78 | GPR119 (0.37) | CHRM2CHRM1CHRM3GPR119HSD11B1 | |
| SCHEMBL30116750 | 0.78 | GPR119 (0.37) | CHRM2CHRM1CHRM3GPR119HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0971918-A1 | BICYCLIC AMINE DERIVATIVES | ZENECA LIMITED (GB) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998046600-A1 | BICYCLIC AMINE DERIVATIVES | ZENECA LIMITED (GB) | 1998-10-22 | — | — | WO | disclosed |