Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP4 | P15090 | 1/20 | 0.57 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.52 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.50 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.49 |
| ▸ | RHOA | P61586 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
| ▸ | PTPRB | P23467 | 1/20 | 0.48 |
| ▸ | CDC25A | P30304 | 1/20 | 0.48 |
| ▸ | CDC25B | P30305 | 1/20 | 0.48 |
| ▸ | PTEN | P60484 | 1/20 | 0.48 |
| ▸ | PTPMT1 | Q8WUK0 | 1/20 | 0.48 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1414024 | 0.88 | ALDH1A1 (0.56) | FABP4PTPN1ALDH1A1SMN1; SMN2NR3C1 | |
| SCHEMBL2767758 | 0.84 | ALDH1A1 (0.55) | FABP4ALDH1A1SMN1; SMN2NR3C1POLB | |
| SCHEMBL246185 | 0.83 | ALDH1A1 (0.53) | PTPN1ALDH1A1SMN1; SMN2NR3C1SIRT1 | |
| SCHEMBL3557388 | 0.82 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2NR3C1POLBKEAP1 | |
| SCHEMBL4360347 | 0.82 | THRA (0.73) | FABP4FFAR1SMN1; SMN2NR3C1POLB | |
| SCHEMBL4350235 | 0.82 | THRA (0.58) | FABP4FFAR1SMN1; SMN2NR3C1POLB | |
| SCHEMBL3559365 | 0.81 | ALDH1A1 (0.52) | PTPN1ALDH1A1SMN1; SMN2NR3C1POLB | |
| SCHEMBL6840091 | 0.81 | NR3C1 (0.54) | ALDH1A1SMN1; SMN2NR3C1POLBKEAP1 | |
| SCHEMBL12017476 | 0.81 | FFAR1 (0.58) | FABP4FFAR1SIRT1ITGB3ITGA2B | |
| SCHEMBL657740 | 0.81 | ALDH1A1 (0.64) | FFAR1ALDH1A1SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101475526-A | Carboxylic acid derivatives inhibiting the binding of integrins to receptors thereof | TEXAS BIOTECHNOLOGY CORP (US) | 2009-07-08 | — | — | CN | claimed |
| CN-1412181-A | Carboxylic acid derivatives inhibiting the binding of integrins to their receptors | TEXAS BIOTECHNOLOGIES CORP (US) | 2003-04-23 | — | — | CN | claimed |
| CN-101475526-B | Carboxylic acid derivatives inhibiting the binding of integrins to receptors thereof | TEXAS BIOTECHNOLOGY CORP | 2011-05-25 | — | — | CN | disclosed |
| CN-101475526-A | Carboxylic acid derivatives inhibiting the binding of integrins to receptors thereof | TEXAS BIOTECHNOLOGY CORP (US) | 2009-07-08 | — | — | CN | disclosed |
| CN-100491353-C | Carboxylic acid derivatives inhibiting the binding of integrins to their receptors | TEXAS BIOTECHNOLOGIES CORP (US) | 2009-05-27 | — | — | CN | disclosed |
| US-6972296-B2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC. (US) | 2005-12-06 | — | — | US | disclosed |
| CN-1412181-A | Carboxylic acid derivatives inhibiting the binding of integrins to their receptors | TEXAS BIOTECHNOLOGIES CORP (US) | 2003-04-23 | — | — | CN | disclosed |