Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 5/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.37 |
| ▸ | SLC9A1 | P19634 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6500326 | 1.00 | P2RX7 (0.44) | P2RX7PTGS2MAPTALDH1A1HPGD | |
| SCHEMBL6500333 | 1.00 | P2RX7 (0.44) | P2RX7PTGS2MAPTALDH1A1HPGD | |
| Iodide SCHEMBL3296051 | 0.99 | P2RX7 (0.43) | P2RX7PTGS2MAPTALDH1A1HPGD | |
| Iodide SCHEMBL3296046 | 0.99 | P2RX7 (0.43) | P2RX7PTGS2MAPTALDH1A1HPGD | |
| Iodide SCHEMBL3296044 | 0.99 | P2RX7 (0.43) | P2RX7PTGS2MAPTALDH1A1HPGD | |
| SCHEMBL6497543 | 0.84 | KMT2A (0.42) | P2RX7PTGS2MAPTMEN1KMT2A | |
| SCHEMBL6497546 | 0.84 | KMT2A (0.42) | P2RX7PTGS2MAPTMEN1KMT2A | |
| SCHEMBL6497535 | 0.84 | KMT2A (0.42) | P2RX7PTGS2MAPTMEN1KMT2A | |
| Iodide SCHEMBL3255284 | 0.82 | KMT2A (0.41) | P2RX7PTGS2MAPTMEN1KMT2A | |
| Iodide SCHEMBL3255289 | 0.82 | KMT2A (0.41) | P2RX7PTGS2MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050026916-A1 | Heterocyclic compounds as P2X7 ion channel blockers | AVENTIS PHARMACEUTICALS INC. (US) | 2005-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050026916-A1 | Heterocyclic compounds as P2X7 ion channel blockers | P2RX3, P2RX2, P2RX5 | P2RX7 5/4885PTGS2 493/4885MAPT 1996/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.