Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.54 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | CTSB | P07858 | 1/20 | 0.52 |
| ▸ | LGMN | Q99538 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CDK8 | P49336 | 1/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30637195 | 0.87 | ALDH1A1 (0.55) | MAPTKDM4EGAAALDH1A1MAPK1 | |
| SCHEMBL27649150 | 0.83 | CDK8 (0.47) | KDM4EALDH1A1MAPK1MEN1KMT2A | |
| SCHEMBL6506837 | 0.81 | CYP11B2 (0.53) | KDM4EALDH1A1MEN1KMT2ACDK8 | |
| SCHEMBL899745 | 0.78 | KMT2A (0.74) | MAPTKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL2165481 | 0.77 | ALDH1A1 (0.67) | MAPTKDM4EGAAALDH1A1MEN1 | |
| SCHEMBL3436315 | 0.77 | ALDH1A1 (0.64) | MAPTKDM4EALDH1A1HSD17B10MEN1 | |
| SCHEMBL6186988 | 0.77 | MAPT (0.57) | MAPTKDM4EALDH1A1MAPK1MEN1 | |
| SCHEMBL18914465 | 0.77 | MEN1 (0.65) | MAPTKDM4EAPOBEC3AAPOBEC3GGAA | |
| SCHEMBL5780030 | 0.76 | CYP11B2 (0.48) | CDK8CYP11B1CYP11B2 | |
| SCHEMBL5812793 | 0.76 | GAA (0.57) | MAPTKDM4EGAAALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005019200-A2 | ARYL PIPERIDINE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-03-03 | — | — | WO | disclosed |