Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Trinitrophenol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 7/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.66 |
| ▸ | MEN1 | O00255 | 3/20 | 0.66 |
| ▸ | HPGD | P15428 | 2/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.66 |
| ▸ | TTR | P02766 | 1/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.66 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.66 |
| ▸ | RECQL | P46063 | 1/20 | 0.66 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.66 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.66 |
| ▸ | HTT | P42858 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trinitrophenol SCHEMBL27383317 | 0.98 | GPR35 (0.65) | GPR35ALDH1A1KMT2AMEN1HPGD | |
| Trinitrophenol SCHEMBL5162282 | 0.90 | GPR35 (0.65) | GPR35ALDH1A1KMT2AMEN1HPGD | |
| Trinitrophenol SCHEMBL29086892 | 0.90 | GPR35 (0.74) | GPR35ALDH1A1KMT2AMEN1HPGD | |
| Trinitrophenol SCHEMBL253750 | 0.89 | GPR35 (0.79) | GPR35ALDH1A1KMT2AMEN1HPGD | |
| Trinitrophenol SCHEMBL8744 | 0.89 | GPR35 (0.79) | GPR35ALDH1A1KMT2AMEN1HPGD | |
| Dinitro Cresol SCHEMBL1982910 | 0.89 | GPR35 (0.86) | GPR35ALDH1A1KMT2AMEN1HPGD | |
| Trinitrophenol SCHEMBL18691159 | 0.87 | GPR35 (0.76) | GPR35ALDH1A1KMT2AMEN1HPGD | |
| Trinitrophenol SCHEMBL2197458 | 0.87 | GPR35 (0.76) | GPR35ALDH1A1KMT2AMEN1HPGD | |
| Trinitrophenol SCHEMBL5908864 | 0.87 | GPR35 (0.76) | GPR35ALDH1A1KMT2AMEN1HPGD | |
| Trinitrophenol SCHEMBL9140811 | 0.87 | GPR35 (0.76) | GPR35ALDH1A1KMT2AMEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 215 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118090887-A | Quantitative evaluation release method for tiny linear defects on surface of round steel | 石钢京诚装备技术有限公司 | 2024-05-28 | — | — | CN | claimed |
| CN-116124550-A | Corrosion method for displaying original austenite grains of nitrogen-containing martensitic stainless steel | 山西太钢不锈钢股份有限公司 | 2023-05-16 | — | — | CN | claimed |
| CN-113549917-A | Corrosive agent and corrosion method for displaying prior austenite grain boundary of martensitic stainless steel | 西安热工研究院有限公司 | 2021-10-26 | — | — | CN | claimed |
| CN-110344060-B | Corrosive agent for displaying coating structure of zinc-iron alloy hot-dip galvanized steel sheet and preparation and use methods thereof | 马鞍山钢铁股份有限公司 | 2021-06-15 | — | — | CN | claimed |
| CN-107957420-B | Method for determining residual austenite of medium-carbon TRIP steel | 攀钢集团攀枝花钢铁研究院有限公司 | 2021-01-26 | — | — | CN | claimed |
| CN-111551577-A | Quantitative analysis method for martensite content in TRIP steel | 马鞍山钢铁股份有限公司 | 2020-08-18 | — | — | CN | claimed |
| CN-108796356-B | Preparation method of nodular cast iron part with composite layer | 佛山市高明康得球铁有限公司 | 2020-01-24 | — | — | CN | claimed |
| CN-105372246-B | For detecting the corrosive agent and its application method of austenitic stainless steel shot blasting on surface layer | 东方电气集团东方锅炉股份有限公司 | 2019-01-29 | — | — | CN | claimed |
| CN-108796356-A | A kind of preparation method of the spheroidal graphite cast-iron product with composite layer | 佛山市高明康得球铁有限公司 | 2018-11-13 | — | — | CN | claimed |
| CN-106092710-B | The display methods of austenite and ferrite dissimilar steel joint metallographic structure | 东方电气集团东方锅炉股份有限公司 | 2018-08-10 | — | — | CN | claimed |
| CN-105483714-B | A kind of processing method of film lithium cell stainless steel substrate | 中国航空工业集团公司北京航空材料研究院 | 2017-12-15 | — | — | CN | claimed |
| CN-106524957-A | Method for measuring dimension of pearlite colony | 武汉钢铁股份有限公司 | 2017-03-22 | — | — | CN | claimed |
| CN-106092710-A | Austenite and the display packing of ferrite dissimilar steel joint metallographic structure | 东方电气集团东方锅炉股份有限公司 | 2016-11-09 | — | — | CN | claimed |
| CN-105483714-A | Treatment method of stainless steel base material for film lithium battery | BEIJING INST AERONAUTICAL MATERIALS AVIAT INDUSTRY CORP CHINA | 2016-04-13 | — | — | CN | claimed |
| CN-103510092-B | Corrosive agent for displaying intergranular cracks of continuous casting billet and preparation method thereof | ANGANG STEEL COMPANY LIMITED (CN) | 2015-10-07 | — | — | CN | claimed |
| CN-102175191-B | Quantitative method for area percent of martensite-austenite (MA) island structure | SHOUGANG CO LTD | 2012-07-25 | — | — | CN | claimed |
| CN-102011119-A | Dual-phase steel color metallographic coloring agent and color display method thereof | MAANSHAN IRON & STEEL CO LTD | 2011-04-13 | — | — | CN | claimed |
| JP-5163590-A | — | — | None | — | — | JP | disclosed |
| US-4001052-A | HOT-ROLLED LOW-CARBON STEEL STRIP WITH AN EXCELLENT PRESS-WORKABILITY CAPABLE OF FORMING SMOOTH PRESSED SURFACE AND A METHOD OF MAKING THE SAME | KAWASAKI STEEL CORPORATION (JA) | 1977-01-04 | — | — | US | disclosed |
| US-3933830-A | FROM 4-(2-PYRIDYLAMIDOETHYL) PYRIDINES REDUCED WITH HYDROGEN AND A NOBLE METAL CATALYST | PFIZER INC. (US) | 1976-01-20 | — | — | US | disclosed |