Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Dinitro Cresol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 7/20 | 0.86 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.86 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | TTR | P02766 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dinitro Cresol SCHEMBL1999566 | 0.93 | GPR35 (0.86) | GPR35ALDH1A1KMT2AMAPK1TDP1 | |
| Dinitro Cresol SCHEMBL4229642 | 0.93 | GPR35 (0.86) | GPR35ALDH1A1KMT2AMAPK1TDP1 | |
| Dinitro Cresol SCHEMBL8873755 | 0.93 | GPR35 (1.00) | GPR35ALDH1A1KMT2AMAPK1TDP1 | |
| Dinitro Cresol SCHEMBL29430312 | 0.93 | GPR35 (1.00) | GPR35ALDH1A1KMT2AMAPK1TDP1 | |
| Dinitro Cresol SCHEMBL20734 | 0.93 | GPR35 (1.00) | GPR35ALDH1A1KMT2AMAPK1TDP1 | |
| Dinitro Cresol SCHEMBL7108490 | 0.91 | GPR35 (0.96) | GPR35ALDH1A1KMT2AMAPK1TDP1 | |
| Dinitro Cresol SCHEMBL9638638 | 0.91 | GPR35 (0.96) | GPR35ALDH1A1KMT2AMAPK1TDP1 | |
| Dinitro Cresol SCHEMBL11029120 | 0.91 | GPR35 (0.96) | GPR35ALDH1A1KMT2AMAPK1TDP1 | |
| Dinitro Cresol SCHEMBL9640831 | 0.91 | GPR35 (0.96) | GPR35ALDH1A1KMT2AMAPK1TDP1 | |
| Dinitro Cresol SCHEMBL6859521 | 0.91 | GPR35 (0.96) | GPR35ALDH1A1KMT2AMAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8697915-B2 | Diamino-alcohol compounds and processes for their manufacture | ANGUS CHEMICAL COMPANY | 2014-04-15 | — | — | US | claimed |
| EP-2518048-A1 | Diamino-alcohol compounds and processes for their manufacture | Dow Global Technologies LLC (US) | 2012-10-31 | — | — | EP | claimed |
| EP-2338872-A2 | Diamino-alcohol compounds and processes for their manufacture | Dow Global Technologies LLC (US) | 2011-06-29 | — | — | EP | claimed |
| US-20110152574-A1 | Novel diamino-alcohol compounds and processes for their manufacture | ADVANCION CORPORATION | 2011-06-23 | — | — | US | claimed |
| US-10696786-B2 | Methods of producing energetic polymers, energetic binders, and energetic compositions | Northrop Grumman Innovation Systems, Inc. (US) | 2020-06-30 | — | — | US | disclosed |
| CN-109896959-A | The preparation method of the fluoro- 2,2- dinitro ethyl alcohol of 2- | 南京理工大学 | 2019-06-18 | — | — | CN | disclosed |
| EP-2518048-B1 | Diamino-alcohol compounds and processes for their manufacture | ANGUS CHEMICAL (US) | 2017-11-22 | — | — | EP | disclosed |
| CN-103987407-B | Pyrrolobenzodiazepines Zhuo and conjugate thereof | 麦迪穆有限责任公司 | 2016-08-24 | — | — | CN | disclosed |
| US-20160168317-A1 | METHODS OF PRODUCING ENERGETIC POLYMERS, ENERGETIC BINDERS, AND ENERGETIC COMPOSITIONS | NORTHROP GRUMMAN SYSTEMS CORPORATION | 2016-06-16 | — | — | US | disclosed |
| CN-103056559-B | Amine, carboxylic acid solder flux composition and welding method | ROHM & HAAS ELECT MATERIALS (US) | 2016-01-06 | — | — | CN | disclosed |
| CN-103028868-B | Polyamine, carboxylic acid flux composition and method of soldering | ROHM & HAAS ELECT MAT | 2015-07-01 | — | — | CN | disclosed |
| CN-102642101-B | Amine flux composition and method of soldering | ROHM & HAAS ELECT MAT | 2015-05-13 | — | — | CN | disclosed |
| EP-2338872-A2 | Diamino-alcohol compounds and processes for their manufacture | Dow Global Technologies LLC (US) | 2011-06-29 | — | — | EP | disclosed |
| US-20110147649-A1 | Novel diamino-alcohol compounds, their manufacture and use in high solids mineral slurries | ADVANCION CORPORATION | 2011-06-23 | — | — | US | disclosed |
| US-20110152407-A1 | Novel diamino-alcohol compounds, their manufacture and use in epoxy resins | ADVANCION CORPORATION | 2011-06-23 | — | — | US | disclosed |
| US-20110152401-A1 | Novel diamino-alcohol compounds, their manufacture and use in coatings applications | ADVANCION CORPORATION | 2011-06-23 | — | — | US | disclosed |
| US-20110152574-A1 | Novel diamino-alcohol compounds and processes for their manufacture | ADVANCION CORPORATION | 2011-06-23 | — | — | US | disclosed |
| CN-1274345-A | Novel diamino compounds, polyamic acid, polyimide, liquid-crystal alignment film made from film of polyimide, and liquid-crystal display element containing same | CHISSO CORP (JP) | 2000-11-22 | — | — | CN | disclosed |
| US-4900851-A | Synthesis of azidodinitro compounds | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE AIR FORCE (US) | 1990-02-13 | — | — | US | disclosed |
| US-4795593-A | 4-azido-4,4-dinitro-1-butanol and derivatives thereof | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE AIR FORCE (US) | 1989-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110152574-A1 | Novel diamino-alcohol compounds and processes for their manufacture | ADH1A, ADH1C, ADH5 | GPR35 3221/4885ALDH1A1 16/4885KMT2A 640/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.