Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | STAT1 | P42224 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | SMO | Q99835 | 6/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MTTP | P55157 | 9/20 | 0.37 |
| ▸ | APOB | P04114 | 6/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6488366 | 0.93 | SMO (0.47) | SMOMTTPAPOB | |
| SCHEMBL6489780 | 0.91 | PDE5A (0.38) | NPC1RAB9AKDM4ESTAT1SMO | |
| SCHEMBL6501137 | 0.85 | PDE5A (0.39) | NPC1RAB9AKDM4ESTAT1MAPT | |
| SCHEMBL6489412 | 0.84 | SMO (0.45) | SMOMTTPAPOB | |
| SCHEMBL6791537 | 0.82 | GAA (0.48) | NPC1RAB9AKDM4ESTAT1MAPT | |
| SCHEMBL6499127 | 0.81 | APOB (0.39) | NPC1RAB9AKDM4EMAPTALDH1A1 | |
| SCHEMBL6795163 | 0.80 | KMT2A (0.38) | NPC1RAB9AKDM4ESTAT1MAPT | |
| SCHEMBL6500792 | 0.80 | NPC1 (0.52) | NPC1RAB9AKDM4ESTAT1MAPT | |
| SCHEMBL6497778 | 0.78 | SREBF2 (0.38) | MAPTALDH1A1SMN1; SMN2F2MEN1 | |
| SCHEMBL6491615 | 0.77 | SREBF2 (0.39) | NPC1RAB9AKDM4EMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050038035-A1 | Heterocyclic amide compounds as apolipoprotein b inhibitors | DAISO CO., LTD. (JP) | 2005-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050038035-A1 | Heterocyclic amide compounds as apolipoprotein b inhibitors | APOB, APOL1, CTRB2 | NPC1 100/4885RAB9A 4382/4885KDM4E 2286/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.