Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.53 |
| ▸ | DAO | P14920 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | GPR35 | Q9HC97 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.53 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | F7 | P08709 | 1/20 | 0.49 |
| ▸ | F3 | P13726 | 1/20 | 0.49 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.49 |
| ▸ | APEX1 | P27695 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | EIF4A3 | P38919 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30119068 | 0.82 | MAP2K1 (0.41) | KDM4EHSD17B10DAOHPGDGPR35 | |
| SCHEMBL15067975 | 0.82 | MAP2K1 (0.41) | KDM4EHSD17B10DAOHPGDGPR35 | |
| SCHEMBL29414290 | 0.76 | DAO (0.58) | KDM4EHSD17B10DAOHPGDGPR35 | |
| SCHEMBL168527 | 0.76 | DAO (0.58) | KDM4EHSD17B10DAOHPGDGPR35 | |
| SCHEMBL1895337 | 0.76 | DAO (0.58) | KDM4EHSD17B10DAOHPGDGPR35 | |
| SCHEMBL25373058 | 0.74 | GPR35 (0.51) | KDM4EHSD17B10DAOHPGDGPR35 | |
| SCHEMBL1824752 | 0.74 | GPR35 (0.51) | KDM4EHSD17B10DAOHPGDGPR35 | |
| SCHEMBL2107838 | 0.74 | PIN1 (0.56) | KDM4EHSD17B10DAOHPGDGPR35 | |
| SCHEMBL1203070 | 0.74 | F7 (0.56) | KDM4EHSD17B10DAOHPGDGPR35 | |
| SCHEMBL4397741 | 0.74 | KDM4E (0.56) | KDM4EHSD17B10DAOHPGDGPR35 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013097052-A1 | BROMODOMAIN INHIBITORS | ABBOTT LABORATORIES (US) | 2013-07-04 | — | — | WO | claimed |
| EP-2797918-A1 | BROMODOMAIN INHIBITORS | AbbVie Inc. (US) | 2014-11-05 | — | — | EP | disclosed |
| WO-2013097601-A1 | BROMODOMAIN INHIBITORS | ABBVIE INC. (US) | 2013-07-04 | — | — | WO | disclosed |
| WO-2013097052-A1 | BROMODOMAIN INHIBITORS | ABBOTT LABORATORIES (US) | 2013-07-04 | — | — | WO | disclosed |
| WO-2005040073-A2 | SOLID PHASE SYNTHESIS OF 3-ARYL-2- INDOLYLCARBOXYLIC ACIDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-05-06 | — | — | WO | disclosed |